TY - JOUR
T1 - Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database
AU - Zhou, Jialun
AU - Elliott, Julian
AU - Li, Patrick C.K.
AU - Lim, Poh Lian
AU - Kiertiburanakul, Sasisopin
AU - Kumarasamy, Nagalingeswaran
AU - Merati, Tuti Parwati
AU - Pujari, Sanjay
AU - Chen, Yi Ming A.
AU - Phanuphak, Praphan
AU - Vonthanak, Saphonn
AU - Sirisanthana, Thira
AU - Sungkanuparph, Somnuek
AU - Lee, Christopher K.C.
AU - Kamarulzaman, Adeeba
AU - Oka, Shinichi
AU - Zhang, Fujie
AU - Tau, Goa
AU - Ditangco, Rossana
N1 - Funding Information:
The TREAT Asia HIV Observational Database is part of the Asia Pacific HIV Observational Database and is an initiative of TREAT Asia, a program of amfAR, The Foundation for AIDS Research, with support from the National Institute of Allergy and Infectious Diseases (NIAID) of the U.S. National Institutes of Health (NIH) as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA) (grant no. U01AI069907), and from the Dutch Ministry of Foreign Affairs through a partnership with Stichting Aids Fonds. The National Centre in HIV Epidemiology and Clinical Research is funded by the Australian Government Department of Health and Ageing, and is affiliated with the Faculty of Medicine, The University of New South Wales. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above.
PY - 2009/4/21
Y1 - 2009/4/21
N2 - Background: To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI.
AB - Background: To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI.
UR - http://www.scopus.com/inward/record.url?scp=65649133108&partnerID=8YFLogxK
U2 - 10.1186/1471-2334-9-46
DO - 10.1186/1471-2334-9-46
M3 - Article
C2 - 19383122
AN - SCOPUS:65649133108
SN - 1471-2334
VL - 9
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
M1 - 46
ER -
