TY - JOUR
T1 - Risedronate reduces intracortical porosity in women with osteoporosis
AU - Borah, Babul
AU - Dufresne, Tom
AU - Nurre, Joe
AU - Phipps, Roger
AU - Chmielewski, Paula
AU - Wagner, Leigh
AU - Lundy, Mark
AU - Bouxsein, Mary
AU - Zebaze, Roger
AU - Seeman, Ego
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Nonvertebral fractures account for 80% of all fractures and their accompanying morbidity and mortality. Despite this, the effect of drug therapy on cortical morphology has received limited attention, partly because cortical bone is believed to remodel less and decrease less with age than trabecular bone. However, the haversian canals traversing the cortex provide a surface for remodeling that produces bone loss, porosity, and cortical fragility. We developed a new method of 3D micro-computed tomography (μCT) to quantify intracortical porosity and the effects of treatment. Women with osteoporosis randomized to risedronate (5 mg/day, n=28) or placebo (n=21) had paired transiliac biopsies at baseline and 5 years imaged using 3D μCT. Pores determined from 8 to 12 slices were stratified by their minor axis length into those 25 to 100 mm (closing cone of haversian canals), 100 to 300 μm (cutting cone of haversian canals), and >300 μm (coalescent cavities). Porosity was analyzed as pore area (percent bone area) and pore density (pore number/mm2). Medians are reported. Risedronate reduced pore area in the 25 to 100, 100 to 300, and 300 to 500 μm ranges over 5 years ( p=.0008, .04, NS, respectively) corresponding to an 18% to 25% reduction. In the placebo group, pore area was unchanged. At 5 years, pore area and pore number/mm 2 in the 25 to 100 μm range were each 17% lower in the risedronate group than in the placebo group (=.02 and .04, respectively). Risedronate is likely to maintain bone strength and reduce nonvertebral fracture risk in part by reducing remodeling and therefore the number and size of intracortical cavities.
AB - Nonvertebral fractures account for 80% of all fractures and their accompanying morbidity and mortality. Despite this, the effect of drug therapy on cortical morphology has received limited attention, partly because cortical bone is believed to remodel less and decrease less with age than trabecular bone. However, the haversian canals traversing the cortex provide a surface for remodeling that produces bone loss, porosity, and cortical fragility. We developed a new method of 3D micro-computed tomography (μCT) to quantify intracortical porosity and the effects of treatment. Women with osteoporosis randomized to risedronate (5 mg/day, n=28) or placebo (n=21) had paired transiliac biopsies at baseline and 5 years imaged using 3D μCT. Pores determined from 8 to 12 slices were stratified by their minor axis length into those 25 to 100 mm (closing cone of haversian canals), 100 to 300 μm (cutting cone of haversian canals), and >300 μm (coalescent cavities). Porosity was analyzed as pore area (percent bone area) and pore density (pore number/mm2). Medians are reported. Risedronate reduced pore area in the 25 to 100, 100 to 300, and 300 to 500 μm ranges over 5 years ( p=.0008, .04, NS, respectively) corresponding to an 18% to 25% reduction. In the placebo group, pore area was unchanged. At 5 years, pore area and pore number/mm 2 in the 25 to 100 μm range were each 17% lower in the risedronate group than in the placebo group (=.02 and .04, respectively). Risedronate is likely to maintain bone strength and reduce nonvertebral fracture risk in part by reducing remodeling and therefore the number and size of intracortical cavities.
KW - 3D micro-computed tomography
KW - Cortical porosity
KW - Haversian canals
KW - Osteoporosis
KW - Risedronate
UR - http://www.scopus.com/inward/record.url?scp=77952109140&partnerID=8YFLogxK
U2 - 10.1359/jbmr.090711
DO - 10.1359/jbmr.090711
M3 - Article
C2 - 19580469
AN - SCOPUS:77952109140
SN - 0884-0431
VL - 25
SP - 41
EP - 47
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 1
ER -