Ring closing metathesis of unprotected peptides

Ellen C. Gleeson, W. Roy Jackson, Andrea J. Robinson

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

An efficient and expedient route to the synthesis of dicarba peptides from protecting group-free sequences is reported using Ru-alkylidene catalysed olefin metathesis. A range of cyclic peptides was prepared from linear peptides containing two Z-crotyl glycine residues. Free amine groups were masked as salts with Brønsted acids preventing in situ catalyst decomposition. Excellent RCM conversion was obtained in both DMF and methanol.

Original languageEnglish
Pages (from-to)9769-9772
Number of pages4
JournalChemical Communications
Volume53
Issue number70
DOIs
Publication statusPublished - 2017

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