Ring-closing metathesis in peptides

Ellen C. Gleeson; W. Roy Jackson; Andrea J. Robinson

doi:10.1016/j.tetlet.2016.08.032

Ring-closing metathesis in peptides

Ellen C. Gleeson
, W. Roy Jackson
, Andrea J. Robinson

School of Chemistry

Research output: Contribution to journal › Review Article › Research › peer-review

37 Citations (Scopus)

Abstract

This review highlights developments in the field of ring-closing metathesis applied to the synthesis of cyclic peptides. Special attention is focussed on the synthesis of dicarba peptides that mimic native cystine containing peptides. Recent advances in the field are discussed, including the stereoselective synthesis of carbon-bridged peptides and RCM in aqueous media.

Original language	English
Pages (from-to)	4325-4333
Number of pages	9
Journal	Tetrahedron Letters
Volume	57
Issue number	39
DOIs	https://doi.org/10.1016/j.tetlet.2016.08.032
Publication status	Published - 28 Sept 2016

Keywords

Cyclic constraints
Dicarba peptides
Olefin metathesis
Peptides
Ring-closing metathesis

Access to Document

10.1016/j.tetlet.2016.08.032

Cite this

@article{65a04802ccfd4dd9950e3d6c5c993cf6,

title = "Ring-closing metathesis in peptides",

abstract = "This review highlights developments in the field of ring-closing metathesis applied to the synthesis of cyclic peptides. Special attention is focussed on the synthesis of dicarba peptides that mimic native cystine containing peptides. Recent advances in the field are discussed, including the stereoselective synthesis of carbon-bridged peptides and RCM in aqueous media.",

keywords = "Cyclic constraints, Dicarba peptides, Olefin metathesis, Peptides, Ring-closing metathesis",

author = "Gleeson, \{Ellen C.\} and Jackson, \{W. Roy\} and Robinson, \{Andrea J.\}",

year = "2016",

month = sep,

day = "28",

doi = "10.1016/j.tetlet.2016.08.032",

language = "English",

volume = "57",

pages = "4325--4333",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "39",

}

TY - JOUR

T1 - Ring-closing metathesis in peptides

AU - Gleeson, Ellen C.

AU - Jackson, W. Roy

AU - Robinson, Andrea J.

PY - 2016/9/28

Y1 - 2016/9/28

N2 - This review highlights developments in the field of ring-closing metathesis applied to the synthesis of cyclic peptides. Special attention is focussed on the synthesis of dicarba peptides that mimic native cystine containing peptides. Recent advances in the field are discussed, including the stereoselective synthesis of carbon-bridged peptides and RCM in aqueous media.

AB - This review highlights developments in the field of ring-closing metathesis applied to the synthesis of cyclic peptides. Special attention is focussed on the synthesis of dicarba peptides that mimic native cystine containing peptides. Recent advances in the field are discussed, including the stereoselective synthesis of carbon-bridged peptides and RCM in aqueous media.

KW - Cyclic constraints

KW - Dicarba peptides

KW - Olefin metathesis

KW - Peptides

KW - Ring-closing metathesis

UR - https://www.scopus.com/pages/publications/84985916592

U2 - 10.1016/j.tetlet.2016.08.032

DO - 10.1016/j.tetlet.2016.08.032

M3 - Review Article

AN - SCOPUS:84985916592

SN - 0040-4039

VL - 57

SP - 4325

EP - 4333

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

Ring-closing metathesis in peptides

Abstract

Keywords

Access to Document

Other files and links

New Conus-derived alpha-conotoxin analgesics for the treatment of chronic pain: Structure, mode of action, delivery and disposition

New metal catalysed tandem routes to nitrogen containing compounds

Cite this

Ring-closing metathesis in peptides

Abstract

Keywords

Access to Document

Other files and links

Projects

New Conus-derived alpha-conotoxin analgesics for the treatment of chronic pain: Structure, mode of action, delivery and disposition

New metal catalysed tandem routes to nitrogen containing compounds

Cite this