Ring-closing metathesis in peptides - the sting is in the tail!

Bianca Van Lierop, Christoph Bornschein, William Jackson, Andrea Robinson

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Performing ring-closing metathesis on resin-bound peptides provides an expedient route to carbocyclic peptidomimetics of medicinal interest. Some sequences are highly resistant to metathesis and special strategies need to be employed to promote viable ring closure. This paper describes an on-resin, alternating solid-phase peptide synthesis-catalysis method to overcome deleterious aggregation phenomena. It can be used to promote high yielding single-ring closures and regioselective multi-ring construction in peptides.
Original languageEnglish
Pages (from-to)806 - 811
Number of pages6
JournalAustralian Journal of Chemistry
Volume64
Issue number6
DOIs
Publication statusPublished - 2011

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