TY - JOUR
T1 - Rind of the rambutan, Nephelium lappaceum, a potential source of natural antioxidants
AU - Palanisamy, Uma
AU - Cheng, Hwee Ming
AU - Masilamani, Theanmalar
AU - Subramaniam, Thavamanithevi
AU - Ling, Lai Teng
AU - Radhakrishnan, Ammu K.
N1 - Funding Information:
This work was supported by the Grant No. 01-01-01-0083 EA001 of the Ministry of Science, Technology and Innovation, Malaysia. The authors would like to thank Ms Jamuna A. for her help in preparing this manuscript.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2008/7/1
Y1 - 2008/7/1
N2 - The rind of rambutan, which is normally discarded was found to contain extremely high antioxidant activity when assessed using several methods. Although having a yield of only 18%, the ethanolic rambutan rind extract had a total phenolic content of 762 ± 10 mg GAE/g extract, which is comparable to that of a commercial preparation of grape seed extract. Comparing the extract's pro-oxidant capabilities with vitamin C, α-tocopherol, grape seed and green tea, the rind had the lowest pro-oxidant capacity. In addition, the extract at 100 μg/ml was seen to limit oxidant-induced cell death (DPPH at 50 μM) by apoptosis to an extent similar to that of grape seed. The extracts were not cytotoxic to normal mouse fibroblast cells or splenocytes while the powderised rind was seen to have heavy metals contents far below the permissible levels for nutraceuticals. Our study for the first time reveals the high phenolic content, low pro-oxidant capacity and strong antioxidant activity of the extract from rind of Nephelium lappaceum. This extract, either alone or in combination with other active principles, can be used in cosmetic, nutraceutical and pharmaceutical applications.
AB - The rind of rambutan, which is normally discarded was found to contain extremely high antioxidant activity when assessed using several methods. Although having a yield of only 18%, the ethanolic rambutan rind extract had a total phenolic content of 762 ± 10 mg GAE/g extract, which is comparable to that of a commercial preparation of grape seed extract. Comparing the extract's pro-oxidant capabilities with vitamin C, α-tocopherol, grape seed and green tea, the rind had the lowest pro-oxidant capacity. In addition, the extract at 100 μg/ml was seen to limit oxidant-induced cell death (DPPH at 50 μM) by apoptosis to an extent similar to that of grape seed. The extracts were not cytotoxic to normal mouse fibroblast cells or splenocytes while the powderised rind was seen to have heavy metals contents far below the permissible levels for nutraceuticals. Our study for the first time reveals the high phenolic content, low pro-oxidant capacity and strong antioxidant activity of the extract from rind of Nephelium lappaceum. This extract, either alone or in combination with other active principles, can be used in cosmetic, nutraceutical and pharmaceutical applications.
KW - Free radical-scavenging activity
KW - Nephelium lappaceum
KW - Nutraceuticals
KW - Phenolic content
KW - Pro-oxidant
KW - Rambutan
UR - http://www.scopus.com/inward/record.url?scp=39149100931&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2007.12.018
DO - 10.1016/j.foodchem.2007.12.018
M3 - Article
AN - SCOPUS:39149100931
SN - 0308-8146
VL - 109
SP - 54
EP - 63
JO - Food Chemistry
JF - Food Chemistry
IS - 1
ER -