Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 289-296 |
| Number of pages | 8 |
| Journal | Neonatology |
| Volume | 109 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 |
Keywords
- Bronchopulmonary dysplasia
- Respiratory morbidity
- Right ventricle
Cite this
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Right ventricular function in infants with bronchopulmonary dysplasia: association with respiratory sequelae. / Sehgal, Arvind; Malikiwi, Andra; Paul, Eldho; Tan, Kenneth Hark Hong; Menahem, Samuel.
In: Neonatology, Vol. 109, No. 4, 2016, p. 289-296.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Right ventricular function in infants with bronchopulmonary dysplasia: association with respiratory sequelae
AU - Sehgal, Arvind
AU - Malikiwi, Andra
AU - Paul, Eldho
AU - Tan, Kenneth Hark Hong
AU - Menahem, Samuel
PY - 2016
Y1 - 2016
N2 - Background: While cor pulmonale has been noted in infants with bronchopulmonary dysplasia (BPD), information on right ventricular (RV) function is limited. Objective: To assess RV function in infants with severe BPD and ascertain correlation with respiratory outcomes. Methods: We prospectively assessed RV function using tissue Doppler imaging (TDI), 2D fractional area change (FAC), M-mode tricuspid annular plane systolic excursion (TAPSE) and myocardial performance index (MPI) using echocardiography. Additionally, we compared RV function with preterm infants with no BPD. Results: Eighteen preterm infants with severe BPD were enrolled at 36 weeks' gestation. Higher E/E' (r = 0.78, p < 0.0001) and lower FAC (r = 0.8, p < 0.0001) showed strong correlations with the subsequent duration of respiratory support. Correlations with TDI isovolumic velocity and Tei index were significant (-0.69, p = 0.002 and 0.58, p = 0.011, respectively). On comparison with infants with no BPD, TDI peak systolic velocities (0.06 ± 0.01 vs. 0.09 ± 0.01 m/s, p < 0.0001), peak isovolumic systolic velocities (0.05 ± 0.009 vs. 0.07 ± 0.008 m/s, p < 0.0001) and RV FAC (31 ± 4.7 vs. 36 ± 3.6%, p = 0.019) were significantly lower. Cardiac relaxation was impaired [higher TDI E/E' ratio (9.6 ± 1.8 vs. 5.2 ± 0.5, p < 0.0001) and higher RV MPI (0.33 ± 0.03 vs. 0.25 ± 0.03, p < 0.0001)]. Conclusions: Impaired RV performance in the infants with severe BPD at 36 weeks' corrected gestation correlated with a longer duration of subsequent respiratory support.
AB - Background: While cor pulmonale has been noted in infants with bronchopulmonary dysplasia (BPD), information on right ventricular (RV) function is limited. Objective: To assess RV function in infants with severe BPD and ascertain correlation with respiratory outcomes. Methods: We prospectively assessed RV function using tissue Doppler imaging (TDI), 2D fractional area change (FAC), M-mode tricuspid annular plane systolic excursion (TAPSE) and myocardial performance index (MPI) using echocardiography. Additionally, we compared RV function with preterm infants with no BPD. Results: Eighteen preterm infants with severe BPD were enrolled at 36 weeks' gestation. Higher E/E' (r = 0.78, p < 0.0001) and lower FAC (r = 0.8, p < 0.0001) showed strong correlations with the subsequent duration of respiratory support. Correlations with TDI isovolumic velocity and Tei index were significant (-0.69, p = 0.002 and 0.58, p = 0.011, respectively). On comparison with infants with no BPD, TDI peak systolic velocities (0.06 ± 0.01 vs. 0.09 ± 0.01 m/s, p < 0.0001), peak isovolumic systolic velocities (0.05 ± 0.009 vs. 0.07 ± 0.008 m/s, p < 0.0001) and RV FAC (31 ± 4.7 vs. 36 ± 3.6%, p = 0.019) were significantly lower. Cardiac relaxation was impaired [higher TDI E/E' ratio (9.6 ± 1.8 vs. 5.2 ± 0.5, p < 0.0001) and higher RV MPI (0.33 ± 0.03 vs. 0.25 ± 0.03, p < 0.0001)]. Conclusions: Impaired RV performance in the infants with severe BPD at 36 weeks' corrected gestation correlated with a longer duration of subsequent respiratory support.
KW - Bronchopulmonary dysplasia
KW - Respiratory morbidity
KW - Right ventricle
U2 - 10.1159/000442967
DO - 10.1159/000442967
M3 - Article
VL - 109
SP - 289
EP - 296
JO - Neonatology
JF - Neonatology
SN - 1661-7800
IS - 4
ER -