Right ventricular function in infants with bronchopulmonary dysplasia: association with respiratory sequelae

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: While cor pulmonale has been noted in infants with bronchopulmonary dysplasia (BPD), information on right ventricular (RV) function is limited. Objective: To assess RV function in infants with severe BPD and ascertain correlation with respiratory outcomes. Methods: We prospectively assessed RV function using tissue Doppler imaging (TDI), 2D fractional area change (FAC), M-mode tricuspid annular plane systolic excursion (TAPSE) and myocardial performance index (MPI) using echocardiography. Additionally, we compared RV function with preterm infants with no BPD. Results: Eighteen preterm infants with severe BPD were enrolled at 36 weeks' gestation. Higher E/E' (r = 0.78, p < 0.0001) and lower FAC (r = 0.8, p < 0.0001) showed strong correlations with the subsequent duration of respiratory support. Correlations with TDI isovolumic velocity and Tei index were significant (-0.69, p = 0.002 and 0.58, p = 0.011, respectively). On comparison with infants with no BPD, TDI peak systolic velocities (0.06 ± 0.01 vs. 0.09 ± 0.01 m/s, p < 0.0001), peak isovolumic systolic velocities (0.05 ± 0.009 vs. 0.07 ± 0.008 m/s, p < 0.0001) and RV FAC (31 ± 4.7 vs. 36 ± 3.6%, p = 0.019) were significantly lower. Cardiac relaxation was impaired [higher TDI E/E' ratio (9.6 ± 1.8 vs. 5.2 ± 0.5, p < 0.0001) and higher RV MPI (0.33 ± 0.03 vs. 0.25 ± 0.03, p < 0.0001)]. Conclusions: Impaired RV performance in the infants with severe BPD at 36 weeks' corrected gestation correlated with a longer duration of subsequent respiratory support.
Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalNeonatology
Volume109
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Bronchopulmonary dysplasia
  • Respiratory morbidity
  • Right ventricle

Cite this

@article{f93625ec21d5429eae0ee880e8ea31a6,
title = "Right ventricular function in infants with bronchopulmonary dysplasia: association with respiratory sequelae",
abstract = "Background: While cor pulmonale has been noted in infants with bronchopulmonary dysplasia (BPD), information on right ventricular (RV) function is limited. Objective: To assess RV function in infants with severe BPD and ascertain correlation with respiratory outcomes. Methods: We prospectively assessed RV function using tissue Doppler imaging (TDI), 2D fractional area change (FAC), M-mode tricuspid annular plane systolic excursion (TAPSE) and myocardial performance index (MPI) using echocardiography. Additionally, we compared RV function with preterm infants with no BPD. Results: Eighteen preterm infants with severe BPD were enrolled at 36 weeks' gestation. Higher E/E' (r = 0.78, p < 0.0001) and lower FAC (r = 0.8, p < 0.0001) showed strong correlations with the subsequent duration of respiratory support. Correlations with TDI isovolumic velocity and Tei index were significant (-0.69, p = 0.002 and 0.58, p = 0.011, respectively). On comparison with infants with no BPD, TDI peak systolic velocities (0.06 ± 0.01 vs. 0.09 ± 0.01 m/s, p < 0.0001), peak isovolumic systolic velocities (0.05 ± 0.009 vs. 0.07 ± 0.008 m/s, p < 0.0001) and RV FAC (31 ± 4.7 vs. 36 ± 3.6{\%}, p = 0.019) were significantly lower. Cardiac relaxation was impaired [higher TDI E/E' ratio (9.6 ± 1.8 vs. 5.2 ± 0.5, p < 0.0001) and higher RV MPI (0.33 ± 0.03 vs. 0.25 ± 0.03, p < 0.0001)]. Conclusions: Impaired RV performance in the infants with severe BPD at 36 weeks' corrected gestation correlated with a longer duration of subsequent respiratory support.",
keywords = "Bronchopulmonary dysplasia, Respiratory morbidity, Right ventricle",
author = "Arvind Sehgal and Andra Malikiwi and Eldho Paul and Tan, {Kenneth Hark Hong} and Samuel Menahem",
year = "2016",
doi = "10.1159/000442967",
language = "English",
volume = "109",
pages = "289--296",
journal = "Neonatology",
issn = "1661-7800",
publisher = "Karger",
number = "4",

}

Right ventricular function in infants with bronchopulmonary dysplasia: association with respiratory sequelae. / Sehgal, Arvind; Malikiwi, Andra; Paul, Eldho; Tan, Kenneth Hark Hong; Menahem, Samuel.

In: Neonatology, Vol. 109, No. 4, 2016, p. 289-296.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Right ventricular function in infants with bronchopulmonary dysplasia: association with respiratory sequelae

AU - Sehgal, Arvind

AU - Malikiwi, Andra

AU - Paul, Eldho

AU - Tan, Kenneth Hark Hong

AU - Menahem, Samuel

PY - 2016

Y1 - 2016

N2 - Background: While cor pulmonale has been noted in infants with bronchopulmonary dysplasia (BPD), information on right ventricular (RV) function is limited. Objective: To assess RV function in infants with severe BPD and ascertain correlation with respiratory outcomes. Methods: We prospectively assessed RV function using tissue Doppler imaging (TDI), 2D fractional area change (FAC), M-mode tricuspid annular plane systolic excursion (TAPSE) and myocardial performance index (MPI) using echocardiography. Additionally, we compared RV function with preterm infants with no BPD. Results: Eighteen preterm infants with severe BPD were enrolled at 36 weeks' gestation. Higher E/E' (r = 0.78, p < 0.0001) and lower FAC (r = 0.8, p < 0.0001) showed strong correlations with the subsequent duration of respiratory support. Correlations with TDI isovolumic velocity and Tei index were significant (-0.69, p = 0.002 and 0.58, p = 0.011, respectively). On comparison with infants with no BPD, TDI peak systolic velocities (0.06 ± 0.01 vs. 0.09 ± 0.01 m/s, p < 0.0001), peak isovolumic systolic velocities (0.05 ± 0.009 vs. 0.07 ± 0.008 m/s, p < 0.0001) and RV FAC (31 ± 4.7 vs. 36 ± 3.6%, p = 0.019) were significantly lower. Cardiac relaxation was impaired [higher TDI E/E' ratio (9.6 ± 1.8 vs. 5.2 ± 0.5, p < 0.0001) and higher RV MPI (0.33 ± 0.03 vs. 0.25 ± 0.03, p < 0.0001)]. Conclusions: Impaired RV performance in the infants with severe BPD at 36 weeks' corrected gestation correlated with a longer duration of subsequent respiratory support.

AB - Background: While cor pulmonale has been noted in infants with bronchopulmonary dysplasia (BPD), information on right ventricular (RV) function is limited. Objective: To assess RV function in infants with severe BPD and ascertain correlation with respiratory outcomes. Methods: We prospectively assessed RV function using tissue Doppler imaging (TDI), 2D fractional area change (FAC), M-mode tricuspid annular plane systolic excursion (TAPSE) and myocardial performance index (MPI) using echocardiography. Additionally, we compared RV function with preterm infants with no BPD. Results: Eighteen preterm infants with severe BPD were enrolled at 36 weeks' gestation. Higher E/E' (r = 0.78, p < 0.0001) and lower FAC (r = 0.8, p < 0.0001) showed strong correlations with the subsequent duration of respiratory support. Correlations with TDI isovolumic velocity and Tei index were significant (-0.69, p = 0.002 and 0.58, p = 0.011, respectively). On comparison with infants with no BPD, TDI peak systolic velocities (0.06 ± 0.01 vs. 0.09 ± 0.01 m/s, p < 0.0001), peak isovolumic systolic velocities (0.05 ± 0.009 vs. 0.07 ± 0.008 m/s, p < 0.0001) and RV FAC (31 ± 4.7 vs. 36 ± 3.6%, p = 0.019) were significantly lower. Cardiac relaxation was impaired [higher TDI E/E' ratio (9.6 ± 1.8 vs. 5.2 ± 0.5, p < 0.0001) and higher RV MPI (0.33 ± 0.03 vs. 0.25 ± 0.03, p < 0.0001)]. Conclusions: Impaired RV performance in the infants with severe BPD at 36 weeks' corrected gestation correlated with a longer duration of subsequent respiratory support.

KW - Bronchopulmonary dysplasia

KW - Respiratory morbidity

KW - Right ventricle

U2 - 10.1159/000442967

DO - 10.1159/000442967

M3 - Article

VL - 109

SP - 289

EP - 296

JO - Neonatology

JF - Neonatology

SN - 1661-7800

IS - 4

ER -