Right atrial dilatation increases inositol-(1,4,5)trisphosphate accumulation Implications for the control of atrial natriuretic peptide release

R. von Harsdorf; R. Lang; M. Fullerton; A. I. Smith; E. A. Woodcock

doi:10.1016/0014-5793(88)81384-X

Right atrial dilatation increases inositol-(1,4,5)trisphosphate accumulation Implications for the control of atrial natriuretic peptide release

R. von Harsdorf, R. Lang, M. Fullerton, A. I. Smith, E. A. Woodcock

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

Stretching the right atrium of isolated perfused [³H]inositol-labelled rat hearts was shown to stimulate the phosphatidyl-inositol turnover pathway as demonstrated by the accumulation of [³H]inositol-(1,4,5)trisphosphate and its degradation products. Stimulation was detectable after 1 min with larger increases observed after 10 or 20 min. These findings demonstrate that the myocardium can respond to dilatation by an activation of the phosphatidylinositol turnover pathway. Such a mechanism has implications for the release of atrial natriuretic peptide following right atrial distention.

Original language	English
Pages (from-to)	201-205
Number of pages	5
Journal	FEBS Letters
Volume	233
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(88)81384-X
Publication status	Published - 6 Jun 1988
Externally published	Yes

Keywords

(Rat heart)
Atrial natriuretic peptide
Atrial stretch
Inositol phosphate
Inositol-(1,4,5)trisphosphate

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10.1016/0014-5793(88)81384-X

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title = "Right atrial dilatation increases inositol-(1,4,5)trisphosphate accumulation Implications for the control of atrial natriuretic peptide release",

abstract = "Stretching the right atrium of isolated perfused [3H]inositol-labelled rat hearts was shown to stimulate the phosphatidyl-inositol turnover pathway as demonstrated by the accumulation of [3H]inositol-(1,4,5)trisphosphate and its degradation products. Stimulation was detectable after 1 min with larger increases observed after 10 or 20 min. These findings demonstrate that the myocardium can respond to dilatation by an activation of the phosphatidylinositol turnover pathway. Such a mechanism has implications for the release of atrial natriuretic peptide following right atrial distention.",

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AU - von Harsdorf, R.

AU - Lang, R.

AU - Fullerton, M.

AU - Smith, A. I.

AU - Woodcock, E. A.

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AB - Stretching the right atrium of isolated perfused [3H]inositol-labelled rat hearts was shown to stimulate the phosphatidyl-inositol turnover pathway as demonstrated by the accumulation of [3H]inositol-(1,4,5)trisphosphate and its degradation products. Stimulation was detectable after 1 min with larger increases observed after 10 or 20 min. These findings demonstrate that the myocardium can respond to dilatation by an activation of the phosphatidylinositol turnover pathway. Such a mechanism has implications for the release of atrial natriuretic peptide following right atrial distention.

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KW - Atrial natriuretic peptide

KW - Atrial stretch

KW - Inositol phosphate

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Right atrial dilatation increases inositol-(1,4,5)trisphosphate accumulation Implications for the control of atrial natriuretic peptide release

Abstract

Keywords

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