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Similar to rifampicin (see Chapter 126, Rifampicin (Rifampin)), rifabutin (also known as ansamycin LM 427) is a derivative of rifamycin S. The most important property of this drug is that it is more active than rifampicin against Mycobacterium avium complex (MAC) in vitro, against this organism growing in alveolar macrophages, and in experimental animals (O’Brien et al., 1987; Perumal et al., 1987; Saito et al., 1988; Young, 1993a; Young, 1993b). The chemical formula of rifabutin is C46H62N4O11 and its molecular weight is 277.23; its molecular structure is shown in Figure 127.1.

Original languageEnglish
Title of host publicationKucers the Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs
EditorsM. Lindsay Grayson
Place of PublicationBoca Raton FL USA
PublisherCRC Press
Number of pages16
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
Publication statusPublished - 2 Oct 2017

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