Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis

Christopher Perry, Emmanuel L.C. De Los Santos, Lona M. Alkhalaf, Gregory L. Challis

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Covering: up to the end of 2017 The roles played by Rieske non-heme iron-dependent oxygenases in natural product biosynthesis are reviewed, with particular focus on experimentally characterised examples. Enzymes belonging to this class are known to catalyse a range of transformations, including oxidative carbocyclisation, N-oxygenation, C-hydroxylation and C-C desaturation. Examples of such enzymes that have yet to be experimentally investigated are also briefly described and their likely functions are discussed.

Original languageEnglish
Pages (from-to)622-632
Number of pages11
JournalNatural Product Reports
Volume35
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018

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