Ribosome's mode of function: Myths, facts and recent results

Itai Wekselman, Chen Davidovich, Ilana Agmon, Ella Zimmerman, Haim Rozenberg, Anat Bashan, Rita Berisio, Ada Yonath

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Abstract

Ribosomes translate the genetic code into proteins in all living cells with extremely high efficiency, owing to their inherent flexibility and to their spectacular architecture. During the last 6 decades, extensive effort has been made to elucidate the molecular mechanisms associated with their function, and a quantum jump has been made in recent years, once the three dimensional structures of ribosomes and their functional complexes have been determined. These illuminated key issues in ribosome function, confirmed various biochemical, genetic, and medical findings, and revealed mechanistic details beyond previous expectation, thus leading to conceptual revolutions, and turning old myths into actual facts.

Original languageEnglish
Pages (from-to)122-130
Number of pages9
JournalJournal of Peptide Science
Volume15
Issue number3
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Antibiotics
  • Nanomachine
  • Peptide biosynthesis
  • Ribosome
  • RNA
  • Tunnel
  • X-ray crystallography

Cite this

Wekselman, I., Davidovich, C., Agmon, I., Zimmerman, E., Rozenberg, H., Bashan, A., Berisio, R., & Yonath, A. (2009). Ribosome's mode of function: Myths, facts and recent results. Journal of Peptide Science, 15(3), 122-130. https://doi.org/10.1002/psc.1077