Rhodium(II,II) Dimer as an Efficient Catalyst for Aziridination of Sulfonamides and Amidation of Steroids

Jiang Lin Liang, Shi Xue Yuan, Philip Wai Hong Chan, Chi Ming Che

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126 Citations (Scopus)


(Matrix Presented) Unsaturated sulfonamides underwent direct intramolecular aziridination catalyzed by Rh2(OAc)4 with Phl(OAc)2 and Al2O3 to give the corresponding aziridine products in excellent yields (up to 98%) and with good to excellent conversions. High turnovers (up to 1375) were achieved. The intermolecular rhodium-catalyzed amidation of cholesteryl acetate with Phl=NTs or Phl(OAc)2/NH2R as the nitrogen source exhibited both excellent regio- and α-selectivity (α/β ratio up to 9:1).

Original languageEnglish
Pages (from-to)4507-4510
Number of pages4
JournalOrganic Letters
Issue number25
Publication statusPublished - 12 Dec 2002
Externally publishedYes

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