Rhodium catalyzed template-assisted distal para-C-H olefination

Uttam Dutta, Sudip Maiti, Sandeep Pimparkar, Siddhartha Maiti, Lawrence R. Gahan, Elizabeth H. Krenske, David W. Lupton, Debabrata Maiti

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33 Citations (Scopus)

Abstract

Rhodium catalysis has been extensively used for ortho-C-H functionalization reactions, and successfully extended to meta-C-H functionalization. Its application to para-C-H activation remains an unmet challenge. Herein we disclose the first example of such a reaction, with the Rh-catalyzed para-C-H olefination of arenes. The use of a Si-linked cyanobiphenyl unit as a traceless directing group leads to highly para-selective arene-olefin couplings.

Original languageEnglish
Pages (from-to)7426-7432
Number of pages7
JournalChemical Science
Volume10
Issue number31
DOIs
Publication statusPublished - 21 Aug 2019

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