Rewriting the transcriptome: Adenosine-to-inosine RNA editing by ADARs

Carl R. Walkley, Jin Billy Li

Research output: Contribution to journalReview ArticleResearchpeer-review

140 Citations (Scopus)

Abstract

One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing.

Original languageEnglish
Article number205
Number of pages13
JournalGenome Biology
Volume18
Issue number1
DOIs
Publication statusPublished - 30 Oct 2017
Externally publishedYes

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