Rewilding immunology

Andrew S Flies; Wild Comparative Immunology Consortium

doi:10.1126/science.abb8664

Rewilding immunology

Andrew S Flies, Wild Comparative Immunology Consortium

Research output: Contribution to journal › Comment / Debate › Other › peer-review

Abstract

The common origin of all species provides a wealth of history recorded in DNA and a lens for understanding human biology. Immunology research has traditionally used rodents as the model of choice. However, translational success has not met its full potential. Broadening immunology research to integrate comparative approaches across species and environments can amplify the potential of immunology to improve the lives of humans and other animals. Additionally, it can lead to discoveries that are not possible in a restricted set of model organisms and environments. For example, the contemporary vaccine era arose from observing human-animal interactions in a real-world environment (cowpox infection protected milkmaids from smallpox). Most emerging infectious diseases (EIDs) originate in domestic and wild animals (1), and the coronavirus disease 2019 (COVID-19) pandemic is a stark reminder of the need to think more holistically about the health of humans and animals.

Original language	English
Pages (from-to)	37-38
Number of pages	2
Journal	Science
Volume	369
Issue number	6499
DOIs	https://doi.org/10.1126/science.abb8664
Publication status	Published - 3 Jul 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.abb8664

ARC Centre of Excellence in Advanced Molecular Imaging
Whisstock, J., Abbey, B., Nugent, K., Quiney, H. M., Godfrey, D. I., Heath, W., Fairlie, D., Chapman, H., Peele, A., Davey, J. & Wittmann, A.
30/06/14 → 31/03/21
Project: Research

Cite this

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title = "Rewilding immunology",

abstract = "The common origin of all species provides a wealth of history recorded in DNA and a lens for understanding human biology. Immunology research has traditionally used rodents as the model of choice. However, translational success has not met its full potential. Broadening immunology research to integrate comparative approaches across species and environments can amplify the potential of immunology to improve the lives of humans and other animals. Additionally, it can lead to discoveries that are not possible in a restricted set of model organisms and environments. For example, the contemporary vaccine era arose from observing human-animal interactions in a real-world environment (cowpox infection protected milkmaids from smallpox). Most emerging infectious diseases (EIDs) originate in domestic and wild animals (1), and the coronavirus disease 2019 (COVID-19) pandemic is a stark reminder of the need to think more holistically about the health of humans and animals.",

author = "Flies, {Andrew S} and {Wild Comparative Immunology Consortium} and {Le Nours}, Jerome and Anne Peters and Jamie Rossjohn",

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doi = "10.1126/science.abb8664",

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T1 - Rewilding immunology

AU - Flies, Andrew S

AU - Wild Comparative Immunology Consortium

AU - Le Nours, Jerome

AU - Peters, Anne

AU - Rossjohn, Jamie

PY - 2020/7/3

Y1 - 2020/7/3

N2 - The common origin of all species provides a wealth of history recorded in DNA and a lens for understanding human biology. Immunology research has traditionally used rodents as the model of choice. However, translational success has not met its full potential. Broadening immunology research to integrate comparative approaches across species and environments can amplify the potential of immunology to improve the lives of humans and other animals. Additionally, it can lead to discoveries that are not possible in a restricted set of model organisms and environments. For example, the contemporary vaccine era arose from observing human-animal interactions in a real-world environment (cowpox infection protected milkmaids from smallpox). Most emerging infectious diseases (EIDs) originate in domestic and wild animals (1), and the coronavirus disease 2019 (COVID-19) pandemic is a stark reminder of the need to think more holistically about the health of humans and animals.

AB - The common origin of all species provides a wealth of history recorded in DNA and a lens for understanding human biology. Immunology research has traditionally used rodents as the model of choice. However, translational success has not met its full potential. Broadening immunology research to integrate comparative approaches across species and environments can amplify the potential of immunology to improve the lives of humans and other animals. Additionally, it can lead to discoveries that are not possible in a restricted set of model organisms and environments. For example, the contemporary vaccine era arose from observing human-animal interactions in a real-world environment (cowpox infection protected milkmaids from smallpox). Most emerging infectious diseases (EIDs) originate in domestic and wild animals (1), and the coronavirus disease 2019 (COVID-19) pandemic is a stark reminder of the need to think more holistically about the health of humans and animals.

U2 - 10.1126/science.abb8664

DO - 10.1126/science.abb8664

M3 - Comment / Debate

SN - 0036-8075

VL - 369

SP - 37

EP - 38

JO - Science

JF - Science

IS - 6499

ER -

Rewilding immunology

Abstract

UN SDGs

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Projects

ARC Centre of Excellence in Advanced Molecular Imaging

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