Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease

Kinan Muhammed, Sanjay Manohar, Michael Ben Yehuda, Trevor T.-J. Chong, George Tofaris, Graham Lennox, Marko Bogdanovic, Michele Hu, Masud Husain

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Abstract

Apathy is a debilitating and under-recognized condition that has a significant impact in many neurodegenerative disorders. In Parkinson's disease, it is now known to contribute to worse outcomes and a reduced quality of life for patients and carers, adding to health costs and extending disease burden. However, despite its clinical importance, there remains limited understanding of mechanisms underlying apathy. Here we investigated if insensitivity to reward might be a contributory factor and examined how this relates to severity of clinical symptoms. To do this we created novel ocular measures that indexed motivation level using pupillary and saccadic response to monetary incentives, allowing reward sensitivity to be evaluated objectively. This approach was tested in 40 patients with Parkinson's disease, 31 elderly age-matched control participants and 20 young healthy volunteers. Thirty patients were examined ON and OFF their dopaminergic medication in two counterbalanced sessions, so that the effect of dopamine on reward sensitivity could be assessed. Pupillary dilation to increasing levels of monetary reward on offer provided quantifiable metrics of motivation in healthy subjects as well as patients. Moreover, pupillary reward sensitivity declined with age. In Parkinson's disease, reduced pupillary modulation by incentives was predictive of apathy severity, and independent of motor impairment and autonomic dysfunction as assessed using overnight heart rate variability measures. Reward sensitivity was further modulated by dopaminergic state, with blunted sensitivity when patients were OFF dopaminergic drugs, both in pupillary response and saccadic peak velocity response to reward. These findings suggest that reward insensitivity may be a contributory mechanism to apathy and provide potential new clinical measures for improved diagnosis and monitoring of apathy.

Original languageEnglish
Pages (from-to)2706-2721
Number of pages16
JournalBrain
Volume139
Issue number10
DOIs
Publication statusPublished - 1 Oct 2016
Externally publishedYes

Keywords

  • apathy
  • drug treatment
  • neuropsychology
  • Parkinson's disease
  • vision

Cite this

Muhammed, K., Manohar, S., Ben Yehuda, M., Chong, T. T-J., Tofaris, G., Lennox, G., ... Husain, M. (2016). Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease. Brain, 139(10), 2706-2721. https://doi.org/10.1093/brain/aww188
Muhammed, Kinan ; Manohar, Sanjay ; Ben Yehuda, Michael ; Chong, Trevor T.-J. ; Tofaris, George ; Lennox, Graham ; Bogdanovic, Marko ; Hu, Michele ; Husain, Masud. / Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease. In: Brain. 2016 ; Vol. 139, No. 10. pp. 2706-2721.
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Muhammed, K, Manohar, S, Ben Yehuda, M, Chong, TT-J, Tofaris, G, Lennox, G, Bogdanovic, M, Hu, M & Husain, M 2016, 'Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease', Brain, vol. 139, no. 10, pp. 2706-2721. https://doi.org/10.1093/brain/aww188

Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease. / Muhammed, Kinan; Manohar, Sanjay; Ben Yehuda, Michael; Chong, Trevor T.-J.; Tofaris, George; Lennox, Graham; Bogdanovic, Marko; Hu, Michele; Husain, Masud.

In: Brain, Vol. 139, No. 10, 01.10.2016, p. 2706-2721.

Research output: Contribution to journalArticleResearchpeer-review

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