Revving the throttle on an oncogene: CDK8 takes the driver seat

Ron Firestein, William C. Hahn

Research output: Contribution to journalReview ArticleResearchpeer-review

32 Citations (Scopus)

Abstract

The Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of β-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regulates β-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear β-catenin activity and identify a novel therapeutic target for β-catenin-driven malignancies.

Original languageEnglish
Pages (from-to)7899-7901
Number of pages3
JournalCancer Research
Volume69
Issue number20
DOIs
Publication statusPublished - 15 Oct 2009

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