Revving the throttle on an oncogene: CDK8 takes the driver seat

Ron Firestein, William C. Hahn

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)

Abstract

The Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of β-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regulates β-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear β-catenin activity and identify a novel therapeutic target for β-catenin-driven malignancies.

Original languageEnglish
Pages (from-to)7899-7901
Number of pages3
JournalCancer Research
Volume69
Issue number20
DOIs
Publication statusPublished - 15 Oct 2009

Cite this

Firestein, Ron ; Hahn, William C. / Revving the throttle on an oncogene : CDK8 takes the driver seat. In: Cancer Research. 2009 ; Vol. 69, No. 20. pp. 7899-7901.
@article{c6f7bef263c8455f9668a3b6949151cd,
title = "Revving the throttle on an oncogene: CDK8 takes the driver seat",
abstract = "The Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of β-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regulates β-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear β-catenin activity and identify a novel therapeutic target for β-catenin-driven malignancies.",
author = "Ron Firestein and Hahn, {William C.}",
year = "2009",
month = "10",
day = "15",
doi = "10.1158/0008-5472.CAN-09-1704",
language = "English",
volume = "69",
pages = "7899--7901",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research (AACR)",
number = "20",

}

Revving the throttle on an oncogene : CDK8 takes the driver seat. / Firestein, Ron; Hahn, William C.

In: Cancer Research, Vol. 69, No. 20, 15.10.2009, p. 7899-7901.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Revving the throttle on an oncogene

T2 - CDK8 takes the driver seat

AU - Firestein, Ron

AU - Hahn, William C.

PY - 2009/10/15

Y1 - 2009/10/15

N2 - The Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of β-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regulates β-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear β-catenin activity and identify a novel therapeutic target for β-catenin-driven malignancies.

AB - The Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of β-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regulates β-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear β-catenin activity and identify a novel therapeutic target for β-catenin-driven malignancies.

UR - http://www.scopus.com/inward/record.url?scp=70350234735&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-09-1704

DO - 10.1158/0008-5472.CAN-09-1704

M3 - Review Article

C2 - 19808961

AN - SCOPUS:70350234735

VL - 69

SP - 7899

EP - 7901

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 20

ER -