TY - JOUR
T1 - Revolutionizing the battle against locally advanced breast cancer
T2 - a comprehensive insight into neoadjuvant radiotherapy
AU - Kong, Xiangyi
AU - Song, Jiarui
AU - Gao, Peng
AU - Gao, Ran
AU - Zhang, Lin
AU - Fang, Yi
AU - Wang, Yipeng
AU - Gao, Jidong
AU - Wang, Jing
N1 - Funding Information:
This work was supported by the China National Key R&D (or Research and Development) Program (Nos. 2020AAA0105000 and 2020AAA0105004), the National Natural Science Foundation of China (Nos. 82173328, 81872160, 82072940, 82103047, and 82102887), the CAMS Innovation Fund for Medical Sciences (CIFMS) (Nos. 2021‐I2M‐C&T‐A‐012, 2021‐I2M‐C&T‐B‐044, and 2022‐I2M‐C&T‐B‐087), the Non‐profit Central Research Institute Fund of Chinese Academy of Medical Sciences (No. 2022‐JKCS‐04), the Young Elite Scientist Sponsorship Program By BAST (No. BYESS2022066 and BYESS2023049), the Beijing Association for Science and Technology's “Golden‐Bridge Seed Funding Program” (No. ZZ22027), the Beijing Hope Run Special Fund of Cancer Foundation of China (Nos. LC2020L01, LC2019L07, and LC2022A19), the Chinese Young Breast Experts Research Project (No. CYBER‐2021‐005), the XianSheng Clinical Research Special Fund of China International Medical Foundation (No. Z‐2014‐06‐2103), and the Beijing Xisike Clinical Oncology Research Foundation (Nos. Y‐Young2021‐0017 and Y‐NESTLE2022QN‐0018).
Publisher Copyright:
© 2023 Wiley Periodicals LLC.
PY - 2024/3
Y1 - 2024/3
N2 - Breast cancer (BC) constitutes one of the most pervasive malignancies affecting the female population. Despite progressive improvements in diagnostic and therapeutic technologies, leading to an increased detection of early stage BCs, locally advanced breast cancer (LABC) persists as a significant clinical challenge. Owing to its poor overall survival (OS) rate, elevated recurrence rate, and high potential for distant metastasis, LABC prominently impacts the comprehensive efficacy of BC treatments. Radiotherapy, encompassing preoperative, intraoperative, and postoperative modalities, is acknowledged as an effective strategy for mitigating BC metastasis and enhancing survival rates among patients. Nevertheless, the domain of preoperative neoadjuvant radiotherapy (NART) remains conspicuously underexplored in clinical studies. Available research suggests that NART can induce tumor volume reduction, provoke fibrotic changes in tumor and adjacent normal tissues, thereby mitigating intraoperative cancer propagation and enhancing the quality of life for LABC patients. This manuscript seeks to provide a review of contemporary research pertaining to LABC and its preoperative radiotherapy.
AB - Breast cancer (BC) constitutes one of the most pervasive malignancies affecting the female population. Despite progressive improvements in diagnostic and therapeutic technologies, leading to an increased detection of early stage BCs, locally advanced breast cancer (LABC) persists as a significant clinical challenge. Owing to its poor overall survival (OS) rate, elevated recurrence rate, and high potential for distant metastasis, LABC prominently impacts the comprehensive efficacy of BC treatments. Radiotherapy, encompassing preoperative, intraoperative, and postoperative modalities, is acknowledged as an effective strategy for mitigating BC metastasis and enhancing survival rates among patients. Nevertheless, the domain of preoperative neoadjuvant radiotherapy (NART) remains conspicuously underexplored in clinical studies. Available research suggests that NART can induce tumor volume reduction, provoke fibrotic changes in tumor and adjacent normal tissues, thereby mitigating intraoperative cancer propagation and enhancing the quality of life for LABC patients. This manuscript seeks to provide a review of contemporary research pertaining to LABC and its preoperative radiotherapy.
KW - locally advanced breast cancer
KW - mastectomy
KW - neoadjuvant radiotherapy
KW - review
UR - http://www.scopus.com/inward/record.url?scp=85176554731&partnerID=8YFLogxK
U2 - 10.1002/med.21998
DO - 10.1002/med.21998
M3 - Review Article
C2 - 37947371
AN - SCOPUS:85176554731
SN - 0198-6325
VL - 44
SP - 606
EP - 631
JO - Medicinal Research Reviews
JF - Medicinal Research Reviews
IS - 2
ER -
