Revisiting the SAR of the antischistosomal aryl hydantoin (Ro 13-3978)

Chunkai Wang, Qingjie Zhao, Mireille Vargas, Jeremy O. Jones, Karen White, David Shackleford, Gong Chen, Jessica Saunders, Alice Ng, Francis Chiu, Yuxiang Dong, Susan Charman, Jennifer Keiser, Jonathan L. Vennerstrom

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16 Citations (Scopus)


The aryl hydantoin 1 (Ro 13-3978) was identified in the early 1980s as a promising antischistosomal lead compound. However, this series of aryl hydantoins produced antiandrogenic side effects in the host, a not unexpected outcome given their close structural similarity to the antiandrogenic drug nilutamide. Building on the known SAR of this compound series, we now describe a number of analogs of 1 designed to maximize structural diversity guided by incorporation of substructures and functional groups known to diminish ligand-androgen receptor interactions. These analogs had calculated polar surface area (PSA), measured LogD7.4, aqueous kinetic solubility, and estimated plasma protein binding values in ranges predictive of good ADME profiles. The principal SAR insight was that the hydantoin core of 1 is required for high antischistosomal activity. We identified several compounds with high antischistosomal efficacy that were less antiandrogenic than 1. These data provide direction for the ongoing optimization of antischistosomal hydantoins.

Original languageEnglish
Pages (from-to)10705-10718
Number of pages14
JournalJournal of Medicinal Chemistry
Issue number23
Publication statusPublished - 8 Dec 2016

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