Revisiting systematic reviews on deprescribing trials to better inform future practice and research

Anne Spinewine; Emily Reeve; Wade Thompson

doi:10.1111/bcp.15864

Revisiting systematic reviews on deprescribing trials to better inform future practice and research

Anne Spinewine, Emily Reeve, Wade Thompson

Centre for Medicine Use and Safety

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Deprescribing aims to address the problem of medication overuse in older adults. There has been an increasing number of systematic reviews of ‘deprescribing’. We aimed to describe the categories of trials included in recent systematic reviews, and to make recommendations for future research. We categorized 122 trials included in eight recent deprescribing systematic reviews into: discontinuation, deprescribing implementation, medication optimisation (including medication initiation) and non-initiation trials. We identified heterogeneity and inconsistency in the categories of trials included in deprescribing systematic reviews. For example, 39 trials (32.0%) involved medication initiation in addition to the deprescribing component. It is now time for international researchers to develop and validate terminology used for trials involving discontinuation/deprescribing of medications, and to provide recommendations for evidence synthesis that will better inform future research, and translation into practice and policy.

Original language	English
Pages (from-to)	3758-3764
Number of pages	7
Journal	British Journal of Clinical Pharmacology
Volume	89
Issue number	12
DOIs	https://doi.org/10.1111/bcp.15864
Publication status	Published - Dec 2023

Keywords

deprescribing
deprescriptions (MeSH)
medication overuse
systematic review

Access to Document

10.1111/bcp.15864

Cite this

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title = "Revisiting systematic reviews on deprescribing trials to better inform future practice and research",

abstract = "Deprescribing aims to address the problem of medication overuse in older adults. There has been an increasing number of systematic reviews of {\textquoteleft}deprescribing{\textquoteright}. We aimed to describe the categories of trials included in recent systematic reviews, and to make recommendations for future research. We categorized 122 trials included in eight recent deprescribing systematic reviews into: discontinuation, deprescribing implementation, medication optimisation (including medication initiation) and non-initiation trials. We identified heterogeneity and inconsistency in the categories of trials included in deprescribing systematic reviews. For example, 39 trials (32.0%) involved medication initiation in addition to the deprescribing component. It is now time for international researchers to develop and validate terminology used for trials involving discontinuation/deprescribing of medications, and to provide recommendations for evidence synthesis that will better inform future research, and translation into practice and policy.",

keywords = "deprescribing, deprescriptions (MeSH), medication overuse, systematic review",

author = "Anne Spinewine and Emily Reeve and Wade Thompson",

note = "Funding Information: The authors thank Jeremy Grimshaw for providing insights into the categorization of trials and the interpretation of data. AS performed this work during a research stay at the Ottawa Hospital Research Institute, and she was supported by a Mobility Grant from Fondation Mont‐Godinne (2021–2022). ER is supported by an NHMRC Investigator Grant (APP1195460). Funding Information: ER is supported by a United States National Institutes of Health (NIH) grant and has received royalties for co‐authoring a chapter on deprescribing in UpToDate and honorarium from the Society of Hospital Pharmacists of Australia (leading workshops on deprescribing). The authors have no other conflict of interest to disclose in relation to this work. Publisher Copyright: {\textcopyright} 2023 British Pharmacological Society.",

year = "2023",

month = dec,

doi = "10.1111/bcp.15864",

language = "English",

volume = "89",

pages = "3758--3764",

journal = "British Journal of Clinical Pharmacology",

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AU - Spinewine, Anne

AU - Reeve, Emily

AU - Thompson, Wade

N1 - Funding Information: The authors thank Jeremy Grimshaw for providing insights into the categorization of trials and the interpretation of data. AS performed this work during a research stay at the Ottawa Hospital Research Institute, and she was supported by a Mobility Grant from Fondation Mont‐Godinne (2021–2022). ER is supported by an NHMRC Investigator Grant (APP1195460). Funding Information: ER is supported by a United States National Institutes of Health (NIH) grant and has received royalties for co‐authoring a chapter on deprescribing in UpToDate and honorarium from the Society of Hospital Pharmacists of Australia (leading workshops on deprescribing). The authors have no other conflict of interest to disclose in relation to this work. Publisher Copyright: © 2023 British Pharmacological Society.

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AB - Deprescribing aims to address the problem of medication overuse in older adults. There has been an increasing number of systematic reviews of ‘deprescribing’. We aimed to describe the categories of trials included in recent systematic reviews, and to make recommendations for future research. We categorized 122 trials included in eight recent deprescribing systematic reviews into: discontinuation, deprescribing implementation, medication optimisation (including medication initiation) and non-initiation trials. We identified heterogeneity and inconsistency in the categories of trials included in deprescribing systematic reviews. For example, 39 trials (32.0%) involved medication initiation in addition to the deprescribing component. It is now time for international researchers to develop and validate terminology used for trials involving discontinuation/deprescribing of medications, and to provide recommendations for evidence synthesis that will better inform future research, and translation into practice and policy.

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Revisiting systematic reviews on deprescribing trials to better inform future practice and research

Abstract

Keywords

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Integration and implementation of deprescribing recommendations to reduce medication induced harm

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Revisiting systematic reviews on deprescribing trials to better inform future practice and research

Abstract

Keywords

Access to Document

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Integration and implementation of deprescribing recommendations to reduce medication induced harm

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