Review the detection and bioinformatic analysis of alternative 3 utr isoforms as potential cancer biomarkers

Nitika Kandhari, Calvin A. Kraupner-Taylor, Paul F. Harrison, David R. Powell, Traude H. Beilharz

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Alternative transcript cleavage and polyadenylation is linked to cancer cell transformation, proliferation and outcome. This has led researchers to develop methods to detect and bioinfor-matically analyse alternative polyadenylation as potential cancer biomarkers. If incorporated into standard prognostic measures such as gene expression and clinical parameters, these could ad-vance cancer prognostic testing and possibly guide therapy. In this review, we focus on the existing methodologies, both experimental and computational, that have been applied to support the use of alternative polyadenylation as cancer biomarkers.

Original languageEnglish
Article number5322
Number of pages18
JournalInternational Journal of Molecular Sciences
Volume22
Issue number10
DOIs
Publication statusPublished - 2 May 2021

Keywords

  • 3 focused RNA-seq
  • Alternative polyadenylation
  • Bioinformatics
  • Cancer biomarkers
  • ScRNA-seq

Cite this