REVIEW: Receptor activity modifying proteins

Patrick Sexton, Anthony L Albiston, Maria Morfis, Nandasena Tilakaratne

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. A similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current state of knowledge of the mechanisms underlying RAMP function.
Original languageEnglish
Pages (from-to)73 - 83
Number of pages11
JournalCellular Signalling
Volume13
Issue number2
Publication statusPublished - 2001

Cite this

Sexton, P., Albiston, A. L., Morfis, M., & Tilakaratne, N. (2001). REVIEW: Receptor activity modifying proteins. Cellular Signalling, 13(2), 73 - 83.
Sexton, Patrick ; Albiston, Anthony L ; Morfis, Maria ; Tilakaratne, Nandasena. / REVIEW: Receptor activity modifying proteins. In: Cellular Signalling. 2001 ; Vol. 13, No. 2. pp. 73 - 83.
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Sexton, P, Albiston, AL, Morfis, M & Tilakaratne, N 2001, 'REVIEW: Receptor activity modifying proteins', Cellular Signalling, vol. 13, no. 2, pp. 73 - 83.

REVIEW: Receptor activity modifying proteins. / Sexton, Patrick; Albiston, Anthony L; Morfis, Maria; Tilakaratne, Nandasena.

In: Cellular Signalling, Vol. 13, No. 2, 2001, p. 73 - 83.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - REVIEW: Receptor activity modifying proteins

AU - Sexton, Patrick

AU - Albiston, Anthony L

AU - Morfis, Maria

AU - Tilakaratne, Nandasena

PY - 2001

Y1 - 2001

N2 - Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. A similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current state of knowledge of the mechanisms underlying RAMP function.

AB - Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. A similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current state of knowledge of the mechanisms underlying RAMP function.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11257451

M3 - Article

VL - 13

SP - 73

EP - 83

JO - Cellular Signalling

JF - Cellular Signalling

SN - 0898-6568

IS - 2

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Sexton P, Albiston AL, Morfis M, Tilakaratne N. REVIEW: Receptor activity modifying proteins. Cellular Signalling. 2001;13(2):73 - 83.