Review of experimental animal models of acute pancreatitis

Kim Hue Su, Christine Cuthbertson, Christopher Christophi

Research output: Contribution to journalReview ArticleResearchpeer-review

132 Citations (Scopus)

Abstract

The underlying mechanisms involved in the pathogenesis of acute pancreatitis are ill understood. The mortality rate of this disease has not significantly improved over the past few decades. Current treatment options are limited, and predominantly aimed at supportive therapy. A key feature of severe acute pancreatitis is the presence of extensive tissue necrosis with both local and systemic manifestations of inflammatory response syndromes. A better understanding of the underlying pathophysiology of severe acute pancreatitis may lead to more targeted therapeutic options, potentially leading to improved survival. Animal models of acute pancreatitis are therefore an essential investigative tool for these aims to be achieved. This review discusses the suitability of recent non-invasive models of acute pancreatitis such as hormone-induced, alcohol-induced, immune-mediated, diet-induced, gene knockout and L-arginine; and invasive models including closed duodenal loop, antegrade pancreatic duct perfusion, biliopancreatic duct injection, combination of secretory hyperstimulation with minimal intraductal bile acid exposure, vascular-induced, ischaemia/reperfusion and duct ligation.

Original languageEnglish
Pages (from-to)264-286
Number of pages23
JournalHPB
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 2006
Externally publishedYes

Keywords

  • Acute pancreatitis
  • Animal models

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