Reversible siRNA-polymer conjugates by RAFT polymerization

Karina L Heredia; Thi Hoa Tam Nguyen; Chienwen Chang; Volga Bulmus; Thomas Paul Davis; Heather D Maynard

doi:10.1039/b804812f

Reversible siRNA-polymer conjugates by RAFT polymerization

Karina L Heredia, Thi Hoa Tam Nguyen, Chienwen Chang, Volga Bulmus, Thomas Paul Davis, Heather D Maynard

Research output: Contribution to journal › Article › Research › peer-review

160 Citations (Scopus)

Abstract

A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described.

Original language	English
Pages (from-to)	3245 - 3247
Number of pages	3
Journal	Chemical Communications
Volume	28
DOIs	https://doi.org/10.1039/b804812f
Publication status	Published - 2008
Externally published	Yes

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10.1039/b804812f

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title = "Reversible siRNA-polymer conjugates by RAFT polymerization",

abstract = "A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described.",

author = "Heredia, {Karina L} and Nguyen, {Thi Hoa Tam} and Chienwen Chang and Volga Bulmus and Davis, {Thomas Paul} and Maynard, {Heather D}",

year = "2008",

doi = "10.1039/b804812f",

language = "English",

volume = "28",

pages = "3245 -- 3247",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "The Royal Society of Chemistry",

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TY - JOUR

T1 - Reversible siRNA-polymer conjugates by RAFT polymerization

AU - Heredia, Karina L

AU - Nguyen, Thi Hoa Tam

AU - Chang, Chienwen

AU - Bulmus, Volga

AU - Davis, Thomas Paul

AU - Maynard, Heather D

PY - 2008

Y1 - 2008

N2 - A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described.

AB - A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described.

UR - http://pubs.rsc.org/en/content/articlepdf/2008/cc/b804812f

U2 - 10.1039/b804812f

DO - 10.1039/b804812f

M3 - Article

SN - 1359-7345

VL - 28

SP - 3245

EP - 3247

JO - Chemical Communications

JF - Chemical Communications

ER -

Reversible siRNA-polymer conjugates by RAFT polymerization

Abstract

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