Reversed-phase high-performance liquid chromatography for the determination of steroid hormones in oral contraceptives

A. M. Bond, I. D. Heritage, M. H. Briggs

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Abstract

Reversed-phase high-performance liquid chromatography with UV detection is studied for the determination of both progestogenic and oestrogenic components of oral contraceptive formulations. The applicability of the assay is demonstrated for a number of different progestogen-oestrogen combinations in both conventional tablet and novel "paper" formulations. The results show that the method developed is a versatile technique for the routine assay of these pharmaceutical formulations.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalJournal of Chromatography A
Volume315
Issue numberC
DOIs
Publication statusPublished - 1984

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