Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice

Christopher Chan, Jeffrey Moore, Klaudia Budzyn, Elizabeth Guida, Henry Diep, Antony Vinh, Emma Susan Jones, Robert E Widdop, James A Armitage, Samy Sakkal, Sharon D Ricardo, Christopher G Sobey, Grant R Drummond

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Abstract

Infiltration of macrophages into the artery wall plays detrimental roles during hypertension by promoting vascular inflammation and endothelial dysfunction, and it occurs via a chemo-attractant action of chemokines on macrophage cytokine receptors. We sought to identify the key chemokine receptors associated with macrophage infiltration into the vascular wall during deoxycorticosterone acetate (DOCA)/salt-induced hypertension in mice and to evaluate the impact of pharmacological inhibition of these receptors on blood pressure and leukocyte accumulation. Mice treated with DOCA/salt for 21 days displayed markedly elevated systolic blood pressure (158+/-2 versus 114+/-5 mm Hg in sham group; P2-fold versus sham; P
Original languageEnglish
Pages (from-to)1207 - 1212
Number of pages6
JournalHypertension
Volume60
Issue number5
DOIs
Publication statusPublished - 2012

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