Reversal of transfusion dependence by tumor necrosis factor inhibitor treatment in a patient with concurrent rheumatoid arthritis and primary myelofibrosis

Anderson Ong, Hang Quach, Michelle Leech

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)

Abstract

Tumor necrosis factor α (TNF-α) is a proinflammatory cytokine with pleiotropic effects. Currently, TNF-α inhibitors are approved by the Food and Drug Administration for a number of diseases including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn disease, and ulcerative colitis. We report a patient with seropositive rheumatoid arthritis with concurrent primary myelofibrosis, who had transfusion-dependent anemia and moderate thrombocytopenia that reversed during treatment with adalimumab. Rheumatoid arthritis and myeloproliferative disorder or myelodysplastic disorder often coexist, and treatment with standard immunosuppressants becomes complex. This report adds to the accumulating evidence of the safety of TNF-α inhibitors when primary myelofibrosis is present and generates discussion for further exploration of the potential therapeutic benefit of TNF-α inhibitors in cytopenias associated with primary myelofibrosis.

Original languageEnglish
Pages (from-to)211-213
Number of pages3
JournalJCR: Journal of Clinical Rheumatology
Volume17
Issue number4
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Keywords

  • Anemia
  • Cytopenia
  • Myelofibrosis
  • Rheumatoid arthritis
  • Thrombocytopenia
  • TNF-α inhibitor

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