Retinal neovascularization is prevented by blockade of the renin-angiotensin system

Christina J. Moravski, Darren J. Kelly, Mark E. Cooper, Richard E. Gilbert, John F. Bertram, Shahnaz Shahinfar, Sandford L. Skinner, Jennifer L. Wilkinson-Berka

Research output: Contribution to journalArticleResearchpeer-review

203 Citations (Scopus)

Abstract

Both angiotensin II and vascular endothelial growth factor are angiogenic agents that have recently been implicated in the pathogenesis of proliferative diabetic retinopathy. In this study, retinal neovascularization was examined in a model of retinopathy of prematurity with the use of neonatal transgenic (mRen-2)27 rats, which overexpress renin in tissues, and Sprague-Dawley rats. Blockers of the renin-angiotensin system were administered during the neovascularization period. The ACE inhibitor lisinopril and the angiotensin type 1 receptor antagonist losartan both increased retinal renin levels and prevented inner retinal blood vessel growth. Quantitative in situ hybridization revealed that the expression of vascular endothelial growth factor and its type 2 receptor in the inner retina and proliferating blood vessels were increased in rats with retinopathy of prematurity. Lisinopril reduced both retinal vascular endothelial growth factor and its type 2 receptor mRNA in retinopathy of prematurity rats, whereas losartan had no effect. It is predicted that agents that interrupt the renin-angiotensin system may play an important role as retinoprotective agents in various forms of proliferative retinopathy.

Original languageEnglish
Pages (from-to)1099-1104
Number of pages6
JournalHypertension
Volume36
Issue number6
DOIs
Publication statusPublished - 1 Jan 2000

Keywords

  • Angiotensin
  • Growth substances
  • Renin
  • Renin-angiotensin system

Cite this