Retinal arteriolar diameter and the prevalence and incidence of hypertension: A systematic review and meta-analysis of their association

Sky K.H. Chew, Jing Xie, Jie Jin Wang

Research output: Contribution to journalReview ArticleResearchpeer-review

35 Citations (Scopus)

Abstract

Hypertension is a leading risk factor for increased mortality and morbidity. One pathogenesis mechanism, increased peripheral vascular resistance, relates to arteriolar diameter. Retinal arterioles, visualized and measured through retinal images, provide an insight into the microvascular structure and hints of peripheral vascular resistance. Multiple studies have demonstrated an inverse association between increasing blood pressure and narrowing retinal arteriolar diameter. This systematic review summarizes the currently available evidence from crosssectional and longitudinal population-based studies that have investigated this association. A meta-analysis of five cross-sectional studies (19,633 adults) provided an averaged regression coefficient of -3.07 μm (95% CI, -3.73, -2.40) narrowing in retinal arteriolar diameter for every 10 mm Hg increase in mean arterial blood pressure. Four longitudinal studies (6,247 adults) with follow-up periods ranging from 3 to 7 years consistently showed that generalized retinal arteriolar narrowing (defined as the lowest tertile, quartile, or quintile in the population) was associated with an increased risk of incident hypertension (meta-analysis odds ratio 1.91; 95% CI, 1.56-2.34).

Original languageEnglish
Pages (from-to)144-151
Number of pages8
JournalCurrent Hypertension Reports
Volume14
Issue number2
DOIs
Publication statusPublished - 1 Apr 2012
Externally publishedYes

Keywords

  • Arteriovenous ratio
  • Blood pressure
  • Children
  • Cross-sectional studies
  • Hypertension
  • Longitudinal studies
  • Low birth weight
  • MABP
  • Mechanisms
  • Metaanalysis
  • Peripheral vascular resistance
  • Population-based studies
  • Retinal arteriolar diameter
  • Risk factors

Cite this

@article{052f8e7539884e6da2c1621c593ee6eb,
title = "Retinal arteriolar diameter and the prevalence and incidence of hypertension: A systematic review and meta-analysis of their association",
abstract = "Hypertension is a leading risk factor for increased mortality and morbidity. One pathogenesis mechanism, increased peripheral vascular resistance, relates to arteriolar diameter. Retinal arterioles, visualized and measured through retinal images, provide an insight into the microvascular structure and hints of peripheral vascular resistance. Multiple studies have demonstrated an inverse association between increasing blood pressure and narrowing retinal arteriolar diameter. This systematic review summarizes the currently available evidence from crosssectional and longitudinal population-based studies that have investigated this association. A meta-analysis of five cross-sectional studies (19,633 adults) provided an averaged regression coefficient of -3.07 μm (95{\%} CI, -3.73, -2.40) narrowing in retinal arteriolar diameter for every 10 mm Hg increase in mean arterial blood pressure. Four longitudinal studies (6,247 adults) with follow-up periods ranging from 3 to 7 years consistently showed that generalized retinal arteriolar narrowing (defined as the lowest tertile, quartile, or quintile in the population) was associated with an increased risk of incident hypertension (meta-analysis odds ratio 1.91; 95{\%} CI, 1.56-2.34).",
keywords = "Arteriovenous ratio, Blood pressure, Children, Cross-sectional studies, Hypertension, Longitudinal studies, Low birth weight, MABP, Mechanisms, Metaanalysis, Peripheral vascular resistance, Population-based studies, Retinal arteriolar diameter, Risk factors",
author = "Chew, {Sky K.H.} and Jing Xie and Wang, {Jie Jin}",
year = "2012",
month = "4",
day = "1",
doi = "10.1007/s11906-012-0252-0",
language = "English",
volume = "14",
pages = "144--151",
journal = "Current Hypertension Reports",
issn = "1522-6417",
publisher = "Springer-Verlag London Ltd.",
number = "2",

}

Retinal arteriolar diameter and the prevalence and incidence of hypertension : A systematic review and meta-analysis of their association. / Chew, Sky K.H.; Xie, Jing; Wang, Jie Jin.

In: Current Hypertension Reports, Vol. 14, No. 2, 01.04.2012, p. 144-151.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Retinal arteriolar diameter and the prevalence and incidence of hypertension

T2 - A systematic review and meta-analysis of their association

AU - Chew, Sky K.H.

AU - Xie, Jing

AU - Wang, Jie Jin

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Hypertension is a leading risk factor for increased mortality and morbidity. One pathogenesis mechanism, increased peripheral vascular resistance, relates to arteriolar diameter. Retinal arterioles, visualized and measured through retinal images, provide an insight into the microvascular structure and hints of peripheral vascular resistance. Multiple studies have demonstrated an inverse association between increasing blood pressure and narrowing retinal arteriolar diameter. This systematic review summarizes the currently available evidence from crosssectional and longitudinal population-based studies that have investigated this association. A meta-analysis of five cross-sectional studies (19,633 adults) provided an averaged regression coefficient of -3.07 μm (95% CI, -3.73, -2.40) narrowing in retinal arteriolar diameter for every 10 mm Hg increase in mean arterial blood pressure. Four longitudinal studies (6,247 adults) with follow-up periods ranging from 3 to 7 years consistently showed that generalized retinal arteriolar narrowing (defined as the lowest tertile, quartile, or quintile in the population) was associated with an increased risk of incident hypertension (meta-analysis odds ratio 1.91; 95% CI, 1.56-2.34).

AB - Hypertension is a leading risk factor for increased mortality and morbidity. One pathogenesis mechanism, increased peripheral vascular resistance, relates to arteriolar diameter. Retinal arterioles, visualized and measured through retinal images, provide an insight into the microvascular structure and hints of peripheral vascular resistance. Multiple studies have demonstrated an inverse association between increasing blood pressure and narrowing retinal arteriolar diameter. This systematic review summarizes the currently available evidence from crosssectional and longitudinal population-based studies that have investigated this association. A meta-analysis of five cross-sectional studies (19,633 adults) provided an averaged regression coefficient of -3.07 μm (95% CI, -3.73, -2.40) narrowing in retinal arteriolar diameter for every 10 mm Hg increase in mean arterial blood pressure. Four longitudinal studies (6,247 adults) with follow-up periods ranging from 3 to 7 years consistently showed that generalized retinal arteriolar narrowing (defined as the lowest tertile, quartile, or quintile in the population) was associated with an increased risk of incident hypertension (meta-analysis odds ratio 1.91; 95% CI, 1.56-2.34).

KW - Arteriovenous ratio

KW - Blood pressure

KW - Children

KW - Cross-sectional studies

KW - Hypertension

KW - Longitudinal studies

KW - Low birth weight

KW - MABP

KW - Mechanisms

KW - Metaanalysis

KW - Peripheral vascular resistance

KW - Population-based studies

KW - Retinal arteriolar diameter

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84862778842&partnerID=8YFLogxK

U2 - 10.1007/s11906-012-0252-0

DO - 10.1007/s11906-012-0252-0

M3 - Review Article

C2 - 22322543

AN - SCOPUS:84862778842

VL - 14

SP - 144

EP - 151

JO - Current Hypertension Reports

JF - Current Hypertension Reports

SN - 1522-6417

IS - 2

ER -