Reticular pseudodrusen

A risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization

Robert P. Finger, Zhichao Wu, Chi D Luu, Frances Kearney, Lauren N Ayton, Lucia M. Lucci, William C. Hubbard, Jill L. Hageman, Gregory Scott Hageman, Robyn H. Guymer

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Abstract

Purpose To determine whether reticular pseudodrusen (RPD) confer an increased risk of progression to late-stage age-related macular degeneration (AMD) in fellow eyes of those recently diagnosed with unilateral choroidal neovascularization (CNV). Design Retrospective study. Participants Two hundred consecutive participants with CNV secondary to AMD in 1 eye and no signs of late-stage AMD in the fellow eye. Methods Clinical examination and comprehensive retinal imaging, including spectral-domain optical coherence tomography, near-infrared reflectance (NIR), and color fundus photography, at baseline and every follow-up visit. Main Outcome Measures Incidence of geographic atrophy (GA) and CNV in the fellow eye. Results Mean age ± standard deviation was 77±7 years, and 61% of the cohort were female. Fifty-eight percent (n = 116) had RPD, 68% had drusen of 125 μm or more, 36% had pigmentary changes, 10% had both drusen of 125 μm or more and pigmentary changes, and 17% had only RPD in their fellow eyes. After a mean follow-up of 2.3 years, CNV developed in 36% of patients and GA developed in 14% of patients. Those with RPD demonstrated late-stage AMD (61% vs. 33.4%; P < 0.001) and GA (22.4% with RPD vs. 2.4% without RPD; P < 0.001) more often. The presence of reticular pseudodrusen was an independent risk factor for the development of GA (hazard ratio [HR], 4.93; P = 0.042), but not for CNV (HR, 1.19; P = 0.500), at least within the follow-up of this study. Both drusen of 125 μm or more and pigmentary changes at baseline were significant risk factors for the development of CNV and GA (HR, 1.96-11.73; P ≤ 0.020). Conclusions Reticular pseudodrusen seem to confer an increased risk of progression to GA, in addition to drusen and pigmentary changes. The presence of RPD needs to be taken into account when discussing a patient's prognosis and planning management.

Original languageEnglish
Pages (from-to)1252-1256
Number of pages5
JournalOphthalmology
Volume121
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Abbreviations and Acronyms
  • age-related macular degeneration
  • AMD
  • choroidal neovascularization
  • CNV
  • GA
  • geographic atrophy
  • hazard ratio
  • HR
  • near-infrared reflectance
  • NIR
  • reticular pseudodrusen
  • RPD
  • SD OCT
  • spectral-domain optical coherence tomography

Cite this

Finger, Robert P. ; Wu, Zhichao ; Luu, Chi D ; Kearney, Frances ; Ayton, Lauren N ; Lucci, Lucia M. ; Hubbard, William C. ; Hageman, Jill L. ; Hageman, Gregory Scott ; Guymer, Robyn H. / Reticular pseudodrusen : A risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization. In: Ophthalmology. 2014 ; Vol. 121, No. 6. pp. 1252-1256.
@article{2c36a549a5da4656b69633d46d5c1b21,
title = "Reticular pseudodrusen: A risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization",
abstract = "Purpose To determine whether reticular pseudodrusen (RPD) confer an increased risk of progression to late-stage age-related macular degeneration (AMD) in fellow eyes of those recently diagnosed with unilateral choroidal neovascularization (CNV). Design Retrospective study. Participants Two hundred consecutive participants with CNV secondary to AMD in 1 eye and no signs of late-stage AMD in the fellow eye. Methods Clinical examination and comprehensive retinal imaging, including spectral-domain optical coherence tomography, near-infrared reflectance (NIR), and color fundus photography, at baseline and every follow-up visit. Main Outcome Measures Incidence of geographic atrophy (GA) and CNV in the fellow eye. Results Mean age ± standard deviation was 77±7 years, and 61{\%} of the cohort were female. Fifty-eight percent (n = 116) had RPD, 68{\%} had drusen of 125 μm or more, 36{\%} had pigmentary changes, 10{\%} had both drusen of 125 μm or more and pigmentary changes, and 17{\%} had only RPD in their fellow eyes. After a mean follow-up of 2.3 years, CNV developed in 36{\%} of patients and GA developed in 14{\%} of patients. Those with RPD demonstrated late-stage AMD (61{\%} vs. 33.4{\%}; P < 0.001) and GA (22.4{\%} with RPD vs. 2.4{\%} without RPD; P < 0.001) more often. The presence of reticular pseudodrusen was an independent risk factor for the development of GA (hazard ratio [HR], 4.93; P = 0.042), but not for CNV (HR, 1.19; P = 0.500), at least within the follow-up of this study. Both drusen of 125 μm or more and pigmentary changes at baseline were significant risk factors for the development of CNV and GA (HR, 1.96-11.73; P ≤ 0.020). Conclusions Reticular pseudodrusen seem to confer an increased risk of progression to GA, in addition to drusen and pigmentary changes. The presence of RPD needs to be taken into account when discussing a patient's prognosis and planning management.",
keywords = "Abbreviations and Acronyms, age-related macular degeneration, AMD, choroidal neovascularization, CNV, GA, geographic atrophy, hazard ratio, HR, near-infrared reflectance, NIR, reticular pseudodrusen, RPD, SD OCT, spectral-domain optical coherence tomography",
author = "Finger, {Robert P.} and Zhichao Wu and Luu, {Chi D} and Frances Kearney and Ayton, {Lauren N} and Lucci, {Lucia M.} and Hubbard, {William C.} and Hageman, {Jill L.} and Hageman, {Gregory Scott} and Guymer, {Robyn H.}",
year = "2014",
doi = "10.1016/j.ophtha.2013.12.034",
language = "English",
volume = "121",
pages = "1252--1256",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier",
number = "6",

}

Finger, RP, Wu, Z, Luu, CD, Kearney, F, Ayton, LN, Lucci, LM, Hubbard, WC, Hageman, JL, Hageman, GS & Guymer, RH 2014, 'Reticular pseudodrusen: A risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization', Ophthalmology, vol. 121, no. 6, pp. 1252-1256. https://doi.org/10.1016/j.ophtha.2013.12.034

Reticular pseudodrusen : A risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization. / Finger, Robert P.; Wu, Zhichao; Luu, Chi D; Kearney, Frances; Ayton, Lauren N; Lucci, Lucia M.; Hubbard, William C.; Hageman, Jill L.; Hageman, Gregory Scott; Guymer, Robyn H.

In: Ophthalmology, Vol. 121, No. 6, 2014, p. 1252-1256.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Reticular pseudodrusen

T2 - A risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization

AU - Finger, Robert P.

AU - Wu, Zhichao

AU - Luu, Chi D

AU - Kearney, Frances

AU - Ayton, Lauren N

AU - Lucci, Lucia M.

AU - Hubbard, William C.

AU - Hageman, Jill L.

AU - Hageman, Gregory Scott

AU - Guymer, Robyn H.

PY - 2014

Y1 - 2014

N2 - Purpose To determine whether reticular pseudodrusen (RPD) confer an increased risk of progression to late-stage age-related macular degeneration (AMD) in fellow eyes of those recently diagnosed with unilateral choroidal neovascularization (CNV). Design Retrospective study. Participants Two hundred consecutive participants with CNV secondary to AMD in 1 eye and no signs of late-stage AMD in the fellow eye. Methods Clinical examination and comprehensive retinal imaging, including spectral-domain optical coherence tomography, near-infrared reflectance (NIR), and color fundus photography, at baseline and every follow-up visit. Main Outcome Measures Incidence of geographic atrophy (GA) and CNV in the fellow eye. Results Mean age ± standard deviation was 77±7 years, and 61% of the cohort were female. Fifty-eight percent (n = 116) had RPD, 68% had drusen of 125 μm or more, 36% had pigmentary changes, 10% had both drusen of 125 μm or more and pigmentary changes, and 17% had only RPD in their fellow eyes. After a mean follow-up of 2.3 years, CNV developed in 36% of patients and GA developed in 14% of patients. Those with RPD demonstrated late-stage AMD (61% vs. 33.4%; P < 0.001) and GA (22.4% with RPD vs. 2.4% without RPD; P < 0.001) more often. The presence of reticular pseudodrusen was an independent risk factor for the development of GA (hazard ratio [HR], 4.93; P = 0.042), but not for CNV (HR, 1.19; P = 0.500), at least within the follow-up of this study. Both drusen of 125 μm or more and pigmentary changes at baseline were significant risk factors for the development of CNV and GA (HR, 1.96-11.73; P ≤ 0.020). Conclusions Reticular pseudodrusen seem to confer an increased risk of progression to GA, in addition to drusen and pigmentary changes. The presence of RPD needs to be taken into account when discussing a patient's prognosis and planning management.

AB - Purpose To determine whether reticular pseudodrusen (RPD) confer an increased risk of progression to late-stage age-related macular degeneration (AMD) in fellow eyes of those recently diagnosed with unilateral choroidal neovascularization (CNV). Design Retrospective study. Participants Two hundred consecutive participants with CNV secondary to AMD in 1 eye and no signs of late-stage AMD in the fellow eye. Methods Clinical examination and comprehensive retinal imaging, including spectral-domain optical coherence tomography, near-infrared reflectance (NIR), and color fundus photography, at baseline and every follow-up visit. Main Outcome Measures Incidence of geographic atrophy (GA) and CNV in the fellow eye. Results Mean age ± standard deviation was 77±7 years, and 61% of the cohort were female. Fifty-eight percent (n = 116) had RPD, 68% had drusen of 125 μm or more, 36% had pigmentary changes, 10% had both drusen of 125 μm or more and pigmentary changes, and 17% had only RPD in their fellow eyes. After a mean follow-up of 2.3 years, CNV developed in 36% of patients and GA developed in 14% of patients. Those with RPD demonstrated late-stage AMD (61% vs. 33.4%; P < 0.001) and GA (22.4% with RPD vs. 2.4% without RPD; P < 0.001) more often. The presence of reticular pseudodrusen was an independent risk factor for the development of GA (hazard ratio [HR], 4.93; P = 0.042), but not for CNV (HR, 1.19; P = 0.500), at least within the follow-up of this study. Both drusen of 125 μm or more and pigmentary changes at baseline were significant risk factors for the development of CNV and GA (HR, 1.96-11.73; P ≤ 0.020). Conclusions Reticular pseudodrusen seem to confer an increased risk of progression to GA, in addition to drusen and pigmentary changes. The presence of RPD needs to be taken into account when discussing a patient's prognosis and planning management.

KW - Abbreviations and Acronyms

KW - age-related macular degeneration

KW - AMD

KW - choroidal neovascularization

KW - CNV

KW - GA

KW - geographic atrophy

KW - hazard ratio

KW - HR

KW - near-infrared reflectance

KW - NIR

KW - reticular pseudodrusen

KW - RPD

KW - SD OCT

KW - spectral-domain optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=84901789786&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2013.12.034

DO - 10.1016/j.ophtha.2013.12.034

M3 - Article

VL - 121

SP - 1252

EP - 1256

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 6

ER -