Retention time reproducibility in comprehensive two-dimensional gas chromatography using cryogenic modulation: II. An interlaboratory study

Robert Shellie, Philip Marriott, Michelle Leus, Jean Pierre Dufour, Luigi Mondello, Giovanni Dugo, Kefu Sun, Bill Winniford, James Griffith, Jim Luong

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Abstract

An interlaboratory survey was conducted to determine the reproducibility of retention times in both the first (1D) and second dimension ( 2D) axes of the two-dimensional separation space, using the longitudinal cryogenic modulation comprehensive two-dimensional gas chromatographic approach. Intralaboratory reproducibility has been demonstrated in part 1 of this investigation [J. Chromatogr. A 968 (2002) 161]. Confidence in absolute retention times (hence component positions) in the two-dimensional separation space is critical to component identification. Comparing data from four independent laboratories, five independent gas chromatographs, five independent LMCS units, and numerous operators has determined that the LMCS cryogenic modulation approach provides reliable comprehensive two-dimensional GC results.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalJournal of Chromatography A
Volume1019
Issue number1-2
DOIs
Publication statusPublished - 26 Nov 2003
Externally publishedYes

Keywords

  • Cryogenic modulation
  • Gas chromatography, comprehensive two-dimensional
  • Reproducibility
  • Retention time

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