Resveratrol as a potential broad-spectrum compound for cancer treatment

Li Kar Stella Tan; Chee Wun How; Jhi Biau Foo; Kooi Yeong Khaw; Bey Hing Goh; Yong Sze Ong

doi:10.3687/pmmb.a0000098

Resveratrol as a potential broad-spectrum compound for cancer treatment

Li Kar Stella Tan, Chee Wun How, Jhi Biau Foo, Kooi Yeong Khaw, Bey Hing Goh, Yong Sze Ong

Malaysia Sch of Pharmacy

Research output: Contribution to journal › Review Article › Research

7 Citations (Scopus)

Abstract

There is a need to shift the paradigm of cancer therapeutic approach. The severe adverse side effects, drug resistance and unaffordable price plagued with chemotherapeutic drugs has spurred the development of “dirty drug”. Natural products, specifically phytochemicals, have gained much attention due to their ability to target multiple interconnected pathways. Resveratrol (RSV), the stilbenes found in red wine, is one of the phytochemicals that exhibits various pharmacological therapeutic effects including cancer. In this review, we highlighted RSV as a potential “broad-spectrum” anticancer compound, by summarising its targeting mechanisms in the pathways relevant to the cancer hallmarks.

Original language	English
Article number	a0000098
Number of pages	8
Journal	Progress in Microbes and Molecular Biology
Volume	3
Issue number	1
DOIs	https://doi.org/10.3687/pmmb.a0000098
Publication status	Published - 6 Feb 2020

Keywords

dirty drug
hallmarks
metabolites
natural product
stilbene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3687/pmmb.a0000098

399340772-oaFinal published version, 635 KBLicence: CC BY

https://journals.hh-publisher.com/index.php/pmmb/article/view/297Licence: CC BY-NC

Cite this

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title = "Resveratrol as a potential broad-spectrum compound for cancer treatment",

abstract = "There is a need to shift the paradigm of cancer therapeutic approach. The severe adverse side effects, drug resistance and unaffordable price plagued with chemotherapeutic drugs has spurred the development of “dirty drug”. Natural products, specifically phytochemicals, have gained much attention due to their ability to target multiple interconnected pathways. Resveratrol (RSV), the stilbenes found in red wine, is one of the phytochemicals that exhibits various pharmacological therapeutic effects including cancer. In this review, we highlighted RSV as a potential “broad-spectrum” anticancer compound, by summarising its targeting mechanisms in the pathways relevant to the cancer hallmarks.",

keywords = "dirty drug, hallmarks, metabolites, natural product, stilbene",

author = "Tan, {Li Kar Stella} and How, {Chee Wun} and Foo, {Jhi Biau} and Khaw, {Kooi Yeong} and Goh, {Bey Hing} and Ong, {Yong Sze}",

note = "Funding Information: The authors would like to acknowledge Monash Tropical Medicine & Biology (TMB) Multidisciplinary Platform and Monash Global Asia in the 21st Century (GA21) research grant (GA-HW-19-L-01 and GA-HW-19-S02) for this study. Publisher Copyright: {\textcopyright} 2020 by Tan LKS and HH Publisher.",

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AU - Tan, Li Kar Stella

AU - How, Chee Wun

AU - Foo, Jhi Biau

AU - Khaw, Kooi Yeong

AU - Goh, Bey Hing

AU - Ong, Yong Sze

N1 - Funding Information: The authors would like to acknowledge Monash Tropical Medicine & Biology (TMB) Multidisciplinary Platform and Monash Global Asia in the 21st Century (GA21) research grant (GA-HW-19-L-01 and GA-HW-19-S02) for this study. Publisher Copyright: © 2020 by Tan LKS and HH Publisher.

PY - 2020/2/6

Y1 - 2020/2/6

N2 - There is a need to shift the paradigm of cancer therapeutic approach. The severe adverse side effects, drug resistance and unaffordable price plagued with chemotherapeutic drugs has spurred the development of “dirty drug”. Natural products, specifically phytochemicals, have gained much attention due to their ability to target multiple interconnected pathways. Resveratrol (RSV), the stilbenes found in red wine, is one of the phytochemicals that exhibits various pharmacological therapeutic effects including cancer. In this review, we highlighted RSV as a potential “broad-spectrum” anticancer compound, by summarising its targeting mechanisms in the pathways relevant to the cancer hallmarks.

AB - There is a need to shift the paradigm of cancer therapeutic approach. The severe adverse side effects, drug resistance and unaffordable price plagued with chemotherapeutic drugs has spurred the development of “dirty drug”. Natural products, specifically phytochemicals, have gained much attention due to their ability to target multiple interconnected pathways. Resveratrol (RSV), the stilbenes found in red wine, is one of the phytochemicals that exhibits various pharmacological therapeutic effects including cancer. In this review, we highlighted RSV as a potential “broad-spectrum” anticancer compound, by summarising its targeting mechanisms in the pathways relevant to the cancer hallmarks.

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KW - hallmarks

KW - metabolites

KW - natural product

KW - stilbene

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ER -

Resveratrol as a potential broad-spectrum compound for cancer treatment

Abstract

Keywords

UN SDGs

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