Resting-state functional MRI of the default mode network in epilepsy

Ofer M. Gonen, Patrick Kwan, Terence J. O'Brien, Elaine Lui, Patricia M. Desmond

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)


The default mode network (DMN) is a major neuronal network that deactivates during goal-directed tasks. Recent advances in neuroimaging have shed light on its structure and function. Alterations in the DMN are increasingly recognized in a range of neurological and psychiatric conditions including epilepsy. This review first describes the current understanding of the DMN in health, normal aging, and disease as it is acquired via resting-state functional magnetic resonance imaging (MRI), before focusing on how it is affected in various types of focal and generalized epilepsy. These findings support the potential use of DMN parameters as future biomarkers in epilepsy research, diagnosis, and management.

Original languageEnglish
Article number107308
Number of pages7
JournalEpilepsy & Behavior
Publication statusPublished - Oct 2020


  • Default mode network
  • Epilepsy
  • Functional connectivity
  • Resting-state fMRI

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