TY - JOUR
T1 - Resting-state fMRI correlations
T2 - from link-wise unreliability to whole brain stability
AU - Pannunzi, Mario
AU - Hindriks, Rikkert
AU - Bettinardi, Ruggero G.
AU - Wenger, Elisabeth
AU - Lisofsky, Nina
AU - Martensson, Johan
AU - Butler, Oisin
AU - Filevich, Elisa
AU - Becker, Maxi
AU - Lochstet, Martyna
AU - Kühn, Simone
AU - Deco, Gustavo
PY - 2017/8/15
Y1 - 2017/8/15
N2 - The functional architecture of spontaneous BOLD fluctuations has been characterized in detail by numerous studies, demonstrating its potential relevance as a biomarker. However, the systematic investigation of its consistency is still in its infancy. Here, we analyze within- and between-subject variability and test-retest reliability of resting-state functional connectivity (FC) in a unique data set comprising multiple fMRI scans (42) from 5 subjects, and 50 single scans from 50 subjects. We adopt a statistical framework that enables us to identify different sources of variability in FC. We show that the low reliability of single links can be significantly improved by using multiple scans per subject. Moreover, in contrast to earlier studies, we show that spatial heterogeneity in FC reliability is not significant. Finally, we demonstrate that despite the low reliability of individual links, the information carried by the whole-brain FC matrix is robust and can be used as a functional fingerprint to identify individual subjects from the population.
AB - The functional architecture of spontaneous BOLD fluctuations has been characterized in detail by numerous studies, demonstrating its potential relevance as a biomarker. However, the systematic investigation of its consistency is still in its infancy. Here, we analyze within- and between-subject variability and test-retest reliability of resting-state functional connectivity (FC) in a unique data set comprising multiple fMRI scans (42) from 5 subjects, and 50 single scans from 50 subjects. We adopt a statistical framework that enables us to identify different sources of variability in FC. We show that the low reliability of single links can be significantly improved by using multiple scans per subject. Moreover, in contrast to earlier studies, we show that spatial heterogeneity in FC reliability is not significant. Finally, we demonstrate that despite the low reliability of individual links, the information carried by the whole-brain FC matrix is robust and can be used as a functional fingerprint to identify individual subjects from the population.
UR - http://www.scopus.com/inward/record.url?scp=85020486374&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2017.06.006
DO - 10.1016/j.neuroimage.2017.06.006
M3 - Article
AN - SCOPUS:85020486374
SN - 1053-8119
VL - 157
SP - 250
EP - 262
JO - NeuroImage
JF - NeuroImage
ER -