Resting-State Cardiac Workload is Related to Both Increased Neocortical Aggregation of Amyloid-β and Relative Impairments in Spatial Working Memory in Pre-Clinical Alzheimer's Disease

Cláudia Yang Santos, Yen Ying Lim, Wen Chih Wu, Jason Timothy Machan, Shahena Polynice, Rachel Schindler, Paul Maruff, Peter Jeffrey Snyder

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4 Citations (Scopus)


We sought to determine whether there is any association between a cardiac workload marker, rate pressure product (RPP), working memory, and cortical amyloid-β (Aβ) burden in 63 cognitively normal midlife adults (Mage = 62.8 years; range = 55 to 75 years) at risk for Alzheimer's disease (AD). The results showa small-to-moderate relationship between increasing cardiacworkload (at rest) and neocortical amyloidosis in individuals at the preclinical stage of AD. Moreover, increasing RPPwas linearly related to increasing relative impairments on a spatial working memory task (R2 = 0.30), but only for those individuals with neuroimaging evidence suggestive of preclinical AD. These results support a relationship between the aggregation of Aβ protein plaques in the neocortex, increased cognitive impairment, and more inefficient myocardial oxygen use in the absence of significant metabolic demands.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalJournal of Alzheimer's Disease
Issue number1
Publication statusPublished - 2016
Externally publishedYes


  • Alzheimer's disease
  • amyloid beta-peptides
  • blood pressure
  • cardiovascular diseases
  • cerebrovascular disorders
  • comorbidity
  • memory
  • mild cognitive impairment
  • risk factors
  • short-term
  • workload

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