Rest and rinse: sleeping rhythms drive brain detox

Leon C.D. Smyth; Benjamin A. Plog; Jonathan Kipnis

doi:10.1016/j.it.2025.02.007

Rest and rinse: sleeping rhythms drive brain detox

Leon C.D. Smyth
, Benjamin A. Plog
, Jonathan Kipnis

Research output: Contribution to journal › Comment / Debate › Other › peer-review

3 Citations (Scopus)

Abstract

Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

Original language	English
Pages (from-to)	189-191
Number of pages	3
Journal	Trends in Immunology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.it.2025.02.007
Publication status	Published - Mar 2025
Externally published	Yes

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10.1016/j.it.2025.02.007Licence: CC BY

Cite this

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title = "Rest and rinse: sleeping rhythms drive brain detox",

abstract = "Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.",

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doi = "10.1016/j.it.2025.02.007",

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AU - Smyth, Leon C.D.

AU - Plog, Benjamin A.

AU - Kipnis, Jonathan

PY - 2025/3

Y1 - 2025/3

N2 - Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

AB - Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

UR - https://www.scopus.com/pages/publications/85219157489

U2 - 10.1016/j.it.2025.02.007

DO - 10.1016/j.it.2025.02.007

M3 - Comment / Debate

C2 - 40023739

AN - SCOPUS:85219157489

SN - 1471-4906

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SP - 189

EP - 191

JO - Trends in Immunology

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IS - 3

ER -

Rest and rinse: sleeping rhythms drive brain detox

Abstract

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