Although drug cues reliably activate the brain s reward system, studies rarely examine how the processing of drug stimuli compares with natural reinforcers or relates to clinical outcomes. Objectives: To determine hedonic responses to natural and drug reinforcers in long-term heroin users and to examine the utility of these responses in predicting future heroin use. Design: Prospective design examining experiential, expressive, reflex modulation, and cortical/attentional responses to opiate-related and affective stimuli. The opiate- dependent group was reassessed a median of 6 months after testing to determine their level of heroin use during the intervening period.
|Pages (from-to)||205 - 213|
|Number of pages||9|
|Journal||Archives of General Psychiatry|
|Publication status||Published - 2009|
Lubman, D., Yucel, M., Kettle, J. W. L., Scaffidi, A., MacKenzie, T., Simmons, J. G., & Allen, N. B. (2009). Responsiveness to drug cues and natural rewards in opiate addiction: associations with later heroin use. Archives of General Psychiatry, 66(2), 205 - 213. https://doi.org/10.1001/archgenpsychiatry.2008.522