Responsiveness to drug cues and natural rewards in opiate addiction: associations with later heroin use

Dan Lubman, Murat Yucel, Jonathan Walter Lisle Kettle, Antonietta Scaffidi, Trudi MacKenzie, Julian G Simmons, Nicholas Brian Allen

Research output: Contribution to journalArticleResearchpeer-review

117 Citations (Scopus)


Although drug cues reliably activate the brain s reward system, studies rarely examine how the processing of drug stimuli compares with natural reinforcers or relates to clinical outcomes. Objectives: To determine hedonic responses to natural and drug reinforcers in long-term heroin users and to examine the utility of these responses in predicting future heroin use. Design: Prospective design examining experiential, expressive, reflex modulation, and cortical/attentional responses to opiate-related and affective stimuli. The opiate- dependent group was reassessed a median of 6 months after testing to determine their level of heroin use during the intervening period.
Original languageEnglish
Pages (from-to)205 - 213
Number of pages9
JournalArchives of General Psychiatry
Issue number2
Publication statusPublished - 2009
Externally publishedYes

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