Responsive self-assembled nanostructured lipid systems for drug delivery and diagnostics

Wye-Khay Fong, Renata Negrini, Jijo J. Vallooran, Raffaele Mezzenga, Ben J. Boyd

Research output: Contribution to journalReview ArticleResearchpeer-review

64 Citations (Scopus)

Abstract

While stimuli-responsive polymers have received a huge amount of attention in the literature, responsive lipid-based mesophase systems offer unique opportunities in biomedical applications such as drug delivery and biosensing. The different mesophase equilibrium structures enables dynamic switching between nanostructures to facilitate drug release or as a transducer for recognition events. In drug delivery, this behavior offers researchers the means to deliver a therapeutic payload at a specific rate and time i.e. ‘on-demand’. This review summarizes the distinctive features of these multifaceted materials and aggregates the current state of the art research from our groups and others into the use of these materials as bulk gels and nanostructured dispersions for drug delivery, biosensing and diagnostics.

Original languageEnglish
Pages (from-to)320-339
Number of pages20
JournalJournal of Colloid and Interface Science
Volume484
DOIs
Publication statusPublished - 15 Dec 2016

Keywords

  • Biosensing
  • Drug delivery
  • Lipid
  • Lyotropic mesophase
  • Stimuli responsive

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