Responsive lipid-based mesophase materials - opportunity for a new class of on demand drug delivery system

Benjamin James Boyd; Wye Khay Fong; Tracey Hanley

Responsive lipid-based mesophase materials - opportunity for a new class of on demand drug delivery system

Benjamin James Boyd, Wye Khay Fong, Tracey Hanley

Drug Delivery Disposition & Dynamics

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

Abstract

The ability of an optimized phytantriol-based liquid crystalline mesophase system to act as a responsive drug delivery matrix has been investigated in vitro and in vivo. Drug release in vitro could be reversibly switched on and off by changes in temperatire. Injection of the matrix into the subcutaneous space, and application of the cool/heat packs to control subcutaneous temperature, allowed control over nanostructure and hence drug release and absorption into plasma, thereby demonstrating one potential application of these symptoms as responsive drug delivery systems.

Original language	English
Title of host publication	36th Annual Meeting & Exposition of the Controlled Release Society
Place of Publication	USA
Publisher	Controlled Release Society
Pages	on cd - on cd
Number of pages	2
Publication status	Published - 2009
Event	Annual Meeting & Exposition of the Controlled Release Society 2009 - Bella Center Coppenhagen Denmark, USA Duration: 1 Jan 2009 → …

Conference

Conference	Annual Meeting & Exposition of the Controlled Release Society 2009
City	USA
Period	1/01/09 → …

Cite this

@inproceedings{92bee91aeb284625bc9009bd4e0aafa1,

title = "Responsive lipid-based mesophase materials - opportunity for a new class of on demand drug delivery system",

abstract = "The ability of an optimized phytantriol-based liquid crystalline mesophase system to act as a responsive drug delivery matrix has been investigated in vitro and in vivo. Drug release in vitro could be reversibly switched on and off by changes in temperatire. Injection of the matrix into the subcutaneous space, and application of the cool/heat packs to control subcutaneous temperature, allowed control over nanostructure and hence drug release and absorption into plasma, thereby demonstrating one potential application of these symptoms as responsive drug delivery systems.",

author = "Boyd, {Benjamin James} and Fong, {Wye Khay} and Tracey Hanley",

year = "2009",

language = "English",

pages = "on cd -- on cd",

booktitle = "36th Annual Meeting & Exposition of the Controlled Release Society",

publisher = "Controlled Release Society",

address = "United States of America",

note = "Annual Meeting & Exposition of the Controlled Release Society 2009 ; Conference date: 01-01-2009",

}

Responsive lipid-based mesophase materials - opportunity for a new class of on demand drug delivery system. / Boyd, Benjamin James ; Fong, Wye Khay; Hanley, Tracey.

36th Annual Meeting & Exposition of the Controlled Release Society. USA : Controlled Release Society, 2009. p. on cd - on cd.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

T1 - Responsive lipid-based mesophase materials - opportunity for a new class of on demand drug delivery system

AU - Boyd, Benjamin James

AU - Fong, Wye Khay

AU - Hanley, Tracey

PY - 2009

Y1 - 2009

N2 - The ability of an optimized phytantriol-based liquid crystalline mesophase system to act as a responsive drug delivery matrix has been investigated in vitro and in vivo. Drug release in vitro could be reversibly switched on and off by changes in temperatire. Injection of the matrix into the subcutaneous space, and application of the cool/heat packs to control subcutaneous temperature, allowed control over nanostructure and hence drug release and absorption into plasma, thereby demonstrating one potential application of these symptoms as responsive drug delivery systems.

AB - The ability of an optimized phytantriol-based liquid crystalline mesophase system to act as a responsive drug delivery matrix has been investigated in vitro and in vivo. Drug release in vitro could be reversibly switched on and off by changes in temperatire. Injection of the matrix into the subcutaneous space, and application of the cool/heat packs to control subcutaneous temperature, allowed control over nanostructure and hence drug release and absorption into plasma, thereby demonstrating one potential application of these symptoms as responsive drug delivery systems.

M3 - Conference Paper

SP - on cd - on cd

BT - 36th Annual Meeting & Exposition of the Controlled Release Society

PB - Controlled Release Society

CY - USA

T2 - Annual Meeting & Exposition of the Controlled Release Society 2009

Y2 - 1 January 2009

ER -