Responsive lipid-based mesophase materials - opportunity for a new class of on demand drug delivery system

Benjamin James Boyd, Wye Khay Fong, Tracey Hanley

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

The ability of an optimized phytantriol-based liquid crystalline mesophase system to act as a responsive drug delivery matrix has been investigated in vitro and in vivo. Drug release in vitro could be reversibly switched on and off by changes in temperatire. Injection of the matrix into the subcutaneous space, and application of the cool/heat packs to control subcutaneous temperature, allowed control over nanostructure and hence drug release and absorption into plasma, thereby demonstrating one potential application of these symptoms as responsive drug delivery systems.
Original languageEnglish
Title of host publication36th Annual Meeting & Exposition of the Controlled Release Society
Place of PublicationUSA
PublisherControlled Release Society
Pageson cd - on cd
Number of pages2
Publication statusPublished - 2009
EventAnnual Meeting & Exposition of the Controlled Release Society 2009 - Bella Center Coppenhagen Denmark, USA
Duration: 1 Jan 2009 → …

Conference

ConferenceAnnual Meeting & Exposition of the Controlled Release Society 2009
CityUSA
Period1/01/09 → …

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