Abstract
The ability of an optimized phytantriol-based liquid crystalline mesophase system to act as a responsive drug delivery matrix has been investigated in vitro and in vivo. Drug release in vitro could be reversibly switched on and off by changes in temperatire. Injection of the matrix into the subcutaneous space, and application of the cool/heat packs to control subcutaneous temperature, allowed control over nanostructure and hence drug release and absorption into plasma, thereby demonstrating one potential application of these symptoms as responsive drug delivery systems.
Original language | English |
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Title of host publication | 36th Annual Meeting & Exposition of the Controlled Release Society |
Place of Publication | USA |
Publisher | Controlled Release Society |
Pages | on cd - on cd |
Number of pages | 2 |
Publication status | Published - 2009 |
Event | Annual Meeting & Exposition of the Controlled Release Society 2009 - Bella Center Coppenhagen Denmark, USA Duration: 1 Jan 2009 → … |
Conference
Conference | Annual Meeting & Exposition of the Controlled Release Society 2009 |
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City | USA |
Period | 1/01/09 → … |