Social disorganization theory positions informal social control as central to neighborhood crime reduction. Although neighborhood ties, fear of crime, and perceived disorder influence the exercise of informal social control, there are significant sex differences for these drivers that might differentially influence men and women’s informal social control actions. Furthermore, these differences may be exaggerated under conditions that activate gendered divisions of labor. We use survey data from 4,000 residents in 148 neighborhoods and employ multilevel logistic regression to examine the relationship between sex and informal social control actions. We find that men are more likely to take action than women; however, our three-way interactions reveal family arrangements moderate the relationship between ties, fear of crime, disorder, and these actions.