Responders to rTMS for depression show increased fronto-midline theta and theta connectivity compared to non-responders

N. W. Bailey, K. E. Hoy, N. C. Rogasch, R. H. Thomson, S. McQueen, D. Elliot, C. M. Sullivan, B. D. Fulcher, Z. J. Daskalakis, P. B. Fitzgerald

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for response prediction. Primary hypotheses We expected higher theta and alpha activity in responders compared to non-responders to rTMS. Methods Fifty patients with treatment resistant depression and twenty controls performed a WM task while electroencephalography (EEG) was recorded. Patients underwent 5–8 weeks of rTMS treatment, repeating the EEG at week 1 (W1). Of the 39 participants with valid WM-related EEG data from baseline and W1, 10 were responders. Comparisons between responders and non-responders were made at baseline and W1 for measures of theta (4–8 Hz), upper alpha (10–12.5 Hz), and gamma (30–45 Hz) power, connectivity, and theta-gamma coupling. The control group's measures were compared to the depression group's baseline measures separately. Results Responders showed higher levels of WM-related fronto-midline theta power and theta connectivity compared to non-responders at baseline and W1. Responder's fronto-midline theta power and connectivity was similar to controls. Responders also showed an increase in gamma connectivity from baseline to W1, with a concurrent improvement in mood and WM reaction times. An unbiased combination of all measures provided mean sensitivity of 0.90 at predicting responders and specificity of 0.92 in a predictive machine learning algorithm. Conclusion Baseline and W1 fronto-midline theta power and theta connectivity show good potential for predicting response to rTMS treatment for depression.

Original languageEnglish
Pages (from-to)190-203
Number of pages14
JournalBrain Stimulation
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Alpha
  • Electroencephalography
  • Response prediction
  • Theta
  • Transcranial magnetic stimulation
  • Treatment resistant depression

Cite this

@article{efe219158e9645f394bc50edf4d7be5f,
title = "Responders to rTMS for depression show increased fronto-midline theta and theta connectivity compared to non-responders",
abstract = "Background Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for response prediction. Primary hypotheses We expected higher theta and alpha activity in responders compared to non-responders to rTMS. Methods Fifty patients with treatment resistant depression and twenty controls performed a WM task while electroencephalography (EEG) was recorded. Patients underwent 5–8 weeks of rTMS treatment, repeating the EEG at week 1 (W1). Of the 39 participants with valid WM-related EEG data from baseline and W1, 10 were responders. Comparisons between responders and non-responders were made at baseline and W1 for measures of theta (4–8 Hz), upper alpha (10–12.5 Hz), and gamma (30–45 Hz) power, connectivity, and theta-gamma coupling. The control group's measures were compared to the depression group's baseline measures separately. Results Responders showed higher levels of WM-related fronto-midline theta power and theta connectivity compared to non-responders at baseline and W1. Responder's fronto-midline theta power and connectivity was similar to controls. Responders also showed an increase in gamma connectivity from baseline to W1, with a concurrent improvement in mood and WM reaction times. An unbiased combination of all measures provided mean sensitivity of 0.90 at predicting responders and specificity of 0.92 in a predictive machine learning algorithm. Conclusion Baseline and W1 fronto-midline theta power and theta connectivity show good potential for predicting response to rTMS treatment for depression.",
keywords = "Alpha, Electroencephalography, Response prediction, Theta, Transcranial magnetic stimulation, Treatment resistant depression",
author = "Bailey, {N. W.} and Hoy, {K. E.} and Rogasch, {N. C.} and Thomson, {R. H.} and S. McQueen and D. Elliot and Sullivan, {C. M.} and Fulcher, {B. D.} and Daskalakis, {Z. J.} and Fitzgerald, {P. B.}",
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Responders to rTMS for depression show increased fronto-midline theta and theta connectivity compared to non-responders. / Bailey, N. W.; Hoy, K. E.; Rogasch, N. C.; Thomson, R. H.; McQueen, S.; Elliot, D.; Sullivan, C. M.; Fulcher, B. D.; Daskalakis, Z. J.; Fitzgerald, P. B.

In: Brain Stimulation, Vol. 11, No. 1, 01.01.2018, p. 190-203.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Responders to rTMS for depression show increased fronto-midline theta and theta connectivity compared to non-responders

AU - Bailey, N. W.

AU - Hoy, K. E.

AU - Rogasch, N. C.

AU - Thomson, R. H.

AU - McQueen, S.

AU - Elliot, D.

AU - Sullivan, C. M.

AU - Fulcher, B. D.

AU - Daskalakis, Z. J.

AU - Fitzgerald, P. B.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for response prediction. Primary hypotheses We expected higher theta and alpha activity in responders compared to non-responders to rTMS. Methods Fifty patients with treatment resistant depression and twenty controls performed a WM task while electroencephalography (EEG) was recorded. Patients underwent 5–8 weeks of rTMS treatment, repeating the EEG at week 1 (W1). Of the 39 participants with valid WM-related EEG data from baseline and W1, 10 were responders. Comparisons between responders and non-responders were made at baseline and W1 for measures of theta (4–8 Hz), upper alpha (10–12.5 Hz), and gamma (30–45 Hz) power, connectivity, and theta-gamma coupling. The control group's measures were compared to the depression group's baseline measures separately. Results Responders showed higher levels of WM-related fronto-midline theta power and theta connectivity compared to non-responders at baseline and W1. Responder's fronto-midline theta power and connectivity was similar to controls. Responders also showed an increase in gamma connectivity from baseline to W1, with a concurrent improvement in mood and WM reaction times. An unbiased combination of all measures provided mean sensitivity of 0.90 at predicting responders and specificity of 0.92 in a predictive machine learning algorithm. Conclusion Baseline and W1 fronto-midline theta power and theta connectivity show good potential for predicting response to rTMS treatment for depression.

AB - Background Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for response prediction. Primary hypotheses We expected higher theta and alpha activity in responders compared to non-responders to rTMS. Methods Fifty patients with treatment resistant depression and twenty controls performed a WM task while electroencephalography (EEG) was recorded. Patients underwent 5–8 weeks of rTMS treatment, repeating the EEG at week 1 (W1). Of the 39 participants with valid WM-related EEG data from baseline and W1, 10 were responders. Comparisons between responders and non-responders were made at baseline and W1 for measures of theta (4–8 Hz), upper alpha (10–12.5 Hz), and gamma (30–45 Hz) power, connectivity, and theta-gamma coupling. The control group's measures were compared to the depression group's baseline measures separately. Results Responders showed higher levels of WM-related fronto-midline theta power and theta connectivity compared to non-responders at baseline and W1. Responder's fronto-midline theta power and connectivity was similar to controls. Responders also showed an increase in gamma connectivity from baseline to W1, with a concurrent improvement in mood and WM reaction times. An unbiased combination of all measures provided mean sensitivity of 0.90 at predicting responders and specificity of 0.92 in a predictive machine learning algorithm. Conclusion Baseline and W1 fronto-midline theta power and theta connectivity show good potential for predicting response to rTMS treatment for depression.

KW - Alpha

KW - Electroencephalography

KW - Response prediction

KW - Theta

KW - Transcranial magnetic stimulation

KW - Treatment resistant depression

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U2 - 10.1016/j.brs.2017.10.015

DO - 10.1016/j.brs.2017.10.015

M3 - Article

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JO - Brain Stimulation

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SN - 1935-861X

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