TY - JOUR
T1 - Respiration and heart rate complexity
T2 - effects of age and gender assessed by band-limited transfer entropy
AU - Nemati, Shamim
AU - Edwards, Bradley A.
AU - Lee, Joon
AU - Pittman-Polletta, Benjamin
AU - Butler, James P
AU - Malhotra, Atul
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Aging and disease are accompanied with a reduction of complex variability in the temporal patterns of heart rate. This reduction has been attributed to a break down of the underlying regulatory feedback mechanisms that maintain a homeodynamic state. Previous work has established the utility of entropy as an index of disorder, for quantification of changes in heart rate complexity. However, questions remain regarding the origin of heart rate complexity and the mechanisms involved in its reduction with aging and disease. In this work we use a newly developed technique based on the concept of band-limited transfer entropy to assess the aging-related changes in contribution of respiration and blood pressure to entropy of heart rate at different frequency bands. Noninvasive measurements of heart beat interval, respiration, and systolic blood pressure were recorded from 20 young (21-34 years) and 20 older (68-85 years) healthy adults. Band-limited transfer entropy analysis revealed a reduction in high-frequency contribution of respiration to heart rate complexity (p<0.001) with normal aging, particularly in men. These results have the potential for dissecting the relative contributions of respiration and blood pressure-related reflexes to heart rate complexity and their degeneration with normal aging.
AB - Aging and disease are accompanied with a reduction of complex variability in the temporal patterns of heart rate. This reduction has been attributed to a break down of the underlying regulatory feedback mechanisms that maintain a homeodynamic state. Previous work has established the utility of entropy as an index of disorder, for quantification of changes in heart rate complexity. However, questions remain regarding the origin of heart rate complexity and the mechanisms involved in its reduction with aging and disease. In this work we use a newly developed technique based on the concept of band-limited transfer entropy to assess the aging-related changes in contribution of respiration and blood pressure to entropy of heart rate at different frequency bands. Noninvasive measurements of heart beat interval, respiration, and systolic blood pressure were recorded from 20 young (21-34 years) and 20 older (68-85 years) healthy adults. Band-limited transfer entropy analysis revealed a reduction in high-frequency contribution of respiration to heart rate complexity (p<0.001) with normal aging, particularly in men. These results have the potential for dissecting the relative contributions of respiration and blood pressure-related reflexes to heart rate complexity and their degeneration with normal aging.
KW - Aging
KW - Entropy
KW - Heart rate variability
KW - Respiratory sinus arrhythmia
UR - http://www.scopus.com/inward/record.url?scp=84899468426&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2013.06.016
DO - 10.1016/j.resp.2013.06.016
M3 - Article
C2 - 23811194
AN - SCOPUS:84881223140
VL - 189
SP - 27
EP - 33
JO - Respiratory Physiology & Neurobiology
JF - Respiratory Physiology & Neurobiology
SN - 1569-9048
IS - 1
ER -