Resolution Revolution: Can GC×GC be considered a super-resolution technique?

We posed the question above at the Riva del Garda ISCC/GC×GC symposium in May – perhaps somewhat rhetorically given that the audience was made up of committed GC×GC researchers. Today, “super-resolution” is a term apparently reserved for the Nobel prize-winning spectroscopic technique that is defined by achieving spectroscopic imaging at wavelengths less than those of light. This feat is accomplished by a combination of the “blinking” of fluorescent emitting centers – for instance, located along a fibril – and the mathematical localization of the center of the emission, which effectively reduces the dispersion of the light and centers it better on the emitting moiety. In this way, a biological feature comprising the emitting centers can be defined with much greater precision.