Residual proteinuria and eGFR predict progression of renal impairment within 2 years in type 2 diabetic patients with nephropathy who are receiving optimal treatment with angiotensin receptor blockers

Sarah E Ivory; David K Packham; Anne Therese Reutens; Rory St John Wolfe; Richard Rohde; Julia B Lewis; Robert Charles Atkins

doi:10.1111/nep.12053

Residual proteinuria and eGFR predict progression of renal impairment within 2 years in type 2 diabetic patients with nephropathy who are receiving optimal treatment with angiotensin receptor blockers

Sarah E Ivory, David K Packham, Anne Therese Reutens, Rory St John Wolfe, Richard Rohde, Julia B Lewis, Robert Charles Atkins

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

Aim Proteinuria and estimated glomerular filtration rate (eGFR) predict progression of renal impairment in type 2 diabetic nephropathy (DN) but are they still predictive when these patients are treated with angiotensin receptor blockers (ARB)? We investigated whether residual (after =3 months of ARB treatment) urinary protein/creatinine ratio (rPCR) or urinary albumin/creatinine ratio (rACR) and residual eGFR (reGFR), predict subsequent progression. Methods One thousand, two hundred and forty-five patients with type 2 DN from two international multi-center studies were analysed. Cross classification of rPCR, rACR with reGFR (rPCR:

Original language	English
Pages (from-to)	516 - 524
Number of pages	9
Journal	Nephrology
Volume	18
Issue number	7
DOIs	https://doi.org/10.1111/nep.12053
Publication status	Published - 2013

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10.1111/nep.12053

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Ivory, S. E., Packham, D. K., Reutens, A. T., Wolfe, R. S. J., Rohde, R., Lewis, J. B., & Atkins, R. C. (2013). Residual proteinuria and eGFR predict progression of renal impairment within 2 years in type 2 diabetic patients with nephropathy who are receiving optimal treatment with angiotensin receptor blockers. Nephrology, 18(7), 516 - 524. https://doi.org/10.1111/nep.12053

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title = "Residual proteinuria and eGFR predict progression of renal impairment within 2 years in type 2 diabetic patients with nephropathy who are receiving optimal treatment with angiotensin receptor blockers",

abstract = "Aim Proteinuria and estimated glomerular filtration rate (eGFR) predict progression of renal impairment in type 2 diabetic nephropathy (DN) but are they still predictive when these patients are treated with angiotensin receptor blockers (ARB)? We investigated whether residual (after =3 months of ARB treatment) urinary protein/creatinine ratio (rPCR) or urinary albumin/creatinine ratio (rACR) and residual eGFR (reGFR), predict subsequent progression. Methods One thousand, two hundred and forty-five patients with type 2 DN from two international multi-center studies were analysed. Cross classification of rPCR, rACR with reGFR (rPCR:",

author = "Ivory, {Sarah E} and Packham, {David K} and Reutens, {Anne Therese} and Wolfe, {Rory St John} and Richard Rohde and Lewis, {Julia B} and Atkins, {Robert Charles}",

year = "2013",

doi = "10.1111/nep.12053",

language = "English",

volume = "18",

pages = "516 -- 524",

journal = "Nephrology",

issn = "1320-5358",

publisher = "Wiley-Blackwell",

number = "7",

}

Residual proteinuria and eGFR predict progression of renal impairment within 2 years in type 2 diabetic patients with nephropathy who are receiving optimal treatment with angiotensin receptor blockers. / Ivory, Sarah E; Packham, David K; Reutens, Anne Therese et al.

In: Nephrology, Vol. 18, No. 7, 2013, p. 516 - 524.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Residual proteinuria and eGFR predict progression of renal impairment within 2 years in type 2 diabetic patients with nephropathy who are receiving optimal treatment with angiotensin receptor blockers

AU - Ivory, Sarah E

AU - Packham, David K

AU - Reutens, Anne Therese

AU - Wolfe, Rory St John

AU - Rohde, Richard

AU - Lewis, Julia B

AU - Atkins, Robert Charles

PY - 2013

Y1 - 2013

N2 - Aim Proteinuria and estimated glomerular filtration rate (eGFR) predict progression of renal impairment in type 2 diabetic nephropathy (DN) but are they still predictive when these patients are treated with angiotensin receptor blockers (ARB)? We investigated whether residual (after =3 months of ARB treatment) urinary protein/creatinine ratio (rPCR) or urinary albumin/creatinine ratio (rACR) and residual eGFR (reGFR), predict subsequent progression. Methods One thousand, two hundred and forty-five patients with type 2 DN from two international multi-center studies were analysed. Cross classification of rPCR, rACR with reGFR (rPCR:

AB - Aim Proteinuria and estimated glomerular filtration rate (eGFR) predict progression of renal impairment in type 2 diabetic nephropathy (DN) but are they still predictive when these patients are treated with angiotensin receptor blockers (ARB)? We investigated whether residual (after =3 months of ARB treatment) urinary protein/creatinine ratio (rPCR) or urinary albumin/creatinine ratio (rACR) and residual eGFR (reGFR), predict subsequent progression. Methods One thousand, two hundred and forty-five patients with type 2 DN from two international multi-center studies were analysed. Cross classification of rPCR, rACR with reGFR (rPCR:

UR - http://onlinelibrary.wiley.com/doi/10.1111/nep.12053/pdf

U2 - 10.1111/nep.12053

DO - 10.1111/nep.12053

M3 - Article

VL - 18

SP - 516

EP - 524

JO - Nephrology

JF - Nephrology

SN - 1320-5358

IS - 7

ER -

Residual proteinuria and eGFR predict progression of renal impairment within 2 years in type 2 diabetic patients with nephropathy who are receiving optimal treatment with angiotensin receptor blockers

Abstract

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