Residual effects in monaural temporary threshold shifts to pure tones

R. Rajan, B. M. Johnstone

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)


Temporary threshold shifts (TTS), of the cochlear action potential in the guinea pig, caused by a high frequency exposure tone could be reduced by a prior exposure at the same frequency but lower intensity. The TTS caused by the initial, low intensity exposure tone was allowed to recover to levels where the thresholds were not significantly different from normal thresholds. Re-exposure at the high intensity now resulted in less TTS being recorded, both at the half-octave point and across the range of frequencies affected by the pure tone, when compared to exposure to the high intensity tone without such priming. This protective effect of prior exposure was not affected by intraperitoneal injections of strychnine, distinguishing it from recent reports of protective mechanisms operative during TTS.

Original languageEnglish
Pages (from-to)185-197
Number of pages13
JournalHearing Research
Issue number2
Publication statusPublished - 1 Jan 1983
Externally publishedYes


  • guinea pig
  • high frequency pure-tone exposure
  • N
  • prior exposure
  • strychnine
  • temporary threshold shift

Cite this