TY - JOUR
T1 - Residential greenness associated with decreased risk of metabolic- dysfunction-associated fatty liver disease
T2 - Evidence from a large population-based epidemiological study
AU - Chen, Lin
AU - Jia, Yiping
AU - Guo, Yuming
AU - Chen, Gongbo
AU - Ciren, Zhuoga
AU - Chen, Heng
AU - Duoji, Zhuoma
AU - Xu, Jie
AU - Yang, Tingting
AU - Xu, Huan
AU - Feng, Shiyu
AU - Jiang, Ye
AU - Guo, Bing
AU - Meng, Qiong
AU - Zhao, Xing
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (Grant No. 81973151 and 82103943 ), China Postdoctoral Science Foundation (Grant No. 2020M683335 ), and Sichuan Science and Technology Program (Grant No. 2020JDJQ0014 ). The CMEC baseline survey was supported by the National Key Research and Development Program of China (Grant No. 2017YFC0907305 ).
Publisher Copyright:
© 2022 The Authors
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Background: Numerous studies have shown that residential greenness positively correlates with enhanced health. Metabolic dysfunction-associated fatty liver disease (MAFLD) affects about a quarter of the population while lacking specific treatments. Given that the association between green space and MAFLD is still unknown, we explored the association between residential greenness and MAFLD as well as the potential mechanisms based on the baseline survey of the China Multi-Ethnic Cohort (CMEC). Methods: Residential greenness was expressed as normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI). MAFLD was assessed through hepatic steatosis, the presence of overweight/obesity, type 2 diabetes mellitus, and evidence of metabolic dysregulation. We used logistic regression to examine the association between NDVI/EVI and the prevalence of MAFLD. Moreover, we utilized causal mediation analyses to explore the role of physical activity and ambient particulate matters (PM1, PM2.5, and PM10) on the association between residential greenness and MAFLD. Results: We included 72,368 participants from the CMEC and found that residential greenness was negatively associated with the prevalence of MAFLD. For an interquartile range (IQR) increase in NDVI500 m and EVI500 m, the odds ratio (OR) of MAFLD were 0.78 (95 %CI: 0.75, 0.81) and 0.81 (95 %CI: 0.78, 0.84), respectively. Greater association between residential greenness and MAFLD was observed among males. Air pollutants and physical activity could mediate a partial effect (8.5–22.9 %) of residential greenness on MAFLD. Conclusion: Higher residential greenness was associated with decreased risk of MAFLD. Moreover, the association was greater among males. The protective effects of residential greenness may be achieved by mitigating the hazardous effects of air pollutants and encouraging physical activity.
AB - Background: Numerous studies have shown that residential greenness positively correlates with enhanced health. Metabolic dysfunction-associated fatty liver disease (MAFLD) affects about a quarter of the population while lacking specific treatments. Given that the association between green space and MAFLD is still unknown, we explored the association between residential greenness and MAFLD as well as the potential mechanisms based on the baseline survey of the China Multi-Ethnic Cohort (CMEC). Methods: Residential greenness was expressed as normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI). MAFLD was assessed through hepatic steatosis, the presence of overweight/obesity, type 2 diabetes mellitus, and evidence of metabolic dysregulation. We used logistic regression to examine the association between NDVI/EVI and the prevalence of MAFLD. Moreover, we utilized causal mediation analyses to explore the role of physical activity and ambient particulate matters (PM1, PM2.5, and PM10) on the association between residential greenness and MAFLD. Results: We included 72,368 participants from the CMEC and found that residential greenness was negatively associated with the prevalence of MAFLD. For an interquartile range (IQR) increase in NDVI500 m and EVI500 m, the odds ratio (OR) of MAFLD were 0.78 (95 %CI: 0.75, 0.81) and 0.81 (95 %CI: 0.78, 0.84), respectively. Greater association between residential greenness and MAFLD was observed among males. Air pollutants and physical activity could mediate a partial effect (8.5–22.9 %) of residential greenness on MAFLD. Conclusion: Higher residential greenness was associated with decreased risk of MAFLD. Moreover, the association was greater among males. The protective effects of residential greenness may be achieved by mitigating the hazardous effects of air pollutants and encouraging physical activity.
KW - Epidemiological study
KW - Greenness
KW - Metabolic dysfunction-associated fatty liver disease
UR - http://www.scopus.com/inward/record.url?scp=85143652794&partnerID=8YFLogxK
U2 - 10.1016/j.ecoenv.2022.114338
DO - 10.1016/j.ecoenv.2022.114338
M3 - Article
C2 - 36508840
AN - SCOPUS:85143652794
SN - 0147-6513
VL - 249
JO - Ecotoxicology and Environmental Safety
JF - Ecotoxicology and Environmental Safety
M1 - 114338
ER -
