Research letters: Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation

Matthew S. Parsons, Liyen Loh, Shayarana Gooneratne, Rob J. Center, Stephen J. Kent

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Antibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes in the context of HIV exposure or infection. Antibody- dependent activation is heightened in NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and their major histocompatibility complex class I ligands during ontogeny. Differentiated NK cells, defined as CD57+, also exhibit enhanced antibody-dependent responsiveness. Although KIRs are more frequently expressed on CD57+ NK cells, the presented data suggest education and differentiation make independent contributions to NK cell anti- HIV envelope antibody-dependent activation.

Original languageEnglish
Pages (from-to)2781-2786
Number of pages6
JournalAIDS
Volume28
Issue number18
DOIs
Publication statusPublished - 28 Nov 2014
Externally publishedYes

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