Requirement of bic/microRNA-155 for normal immune function

Antony Rodriguez, Elena Vigorito, Simon Clare, Madhuri V. Warren, Philippe Couttet, Dalya R. Soond, Stijn Van Dongen, Russell J. Grocock, Partha P. Das, Eric A. Miska, David Vetrie, Klaus Okkenhaug, Anton J. Enright, Gordon Dougan, Martin Turner, Allan Bradley

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1421 Citations (Scopus)

Abstract

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

Original languageEnglish
Pages (from-to)608-611
Number of pages4
JournalScience
Volume316
Issue number5824
DOIs
Publication statusPublished - 27 Apr 2007
Externally publishedYes

Cite this

Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., Van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., Vetrie, D., Okkenhaug, K., Enright, A. J., Dougan, G., Turner, M., & Bradley, A. (2007). Requirement of bic/microRNA-155 for normal immune function. Science, 316(5824), 608-611. https://doi.org/10.1126/science.1139253