Repurposing antihypertensive drugs for the management of Alzheimer’s disease

Christine Shing Wei Law, Keng Yoon Yeong

    Research output: Contribution to journalReview ArticleOtherpeer-review

    2 Citations (Scopus)

    Abstract

    Alzheimer’s disease (AD) is a neurodegenerative disorder that has affected millions of people worldwide. However, currently, there is no treatment to cure the disease. The AD drugs available in the market only manage the disease symptomatically and the effects are usually short-term. Thus, there is a need to look at alternatives AD therapies. This literature review aims to shed some light on the potential of repurposing antihypertensives to treat AD. Mid-life hypertension has not only been recognised as a risk factor for AD, but its relation with AD has also been well established. Hence, antihypertensives were postulated to be beneficial in managing AD. Four classes of antihypertensives, as well as their potential limitations and prospects in being utilised as AD therapeutics, were discussed in this review.

    Original languageEnglish
    Pages (from-to)1716-1730
    Number of pages15
    JournalCurrent Medicinal Chemistry
    Volume28
    Issue number9
    DOIs
    Publication statusPublished - 2021

    Keywords

    • ACE inhibitors
    • Alzheimer’s disease
    • Anti-hypertensive
    • AT inhibitors
    • Beta-blockers
    • Calcium channel blockers
    • Drug repurposing

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