Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion

Shannon Burke, Juexuan Wang, Xiongfeng Chen, Mariaestela Ortiz, Song Choon Lee, Dong Lu, Lia Campos, David Goulding, Bee Ling Ng, Gordon Dougan, Brian Huntly, Bertie Gottgens, Nancy A. Jenkins, Neal G. Copeland, Francesco Colucci, Pentao Liu

Research output: Contribution to journalArticleResearchpeer-review

220 Citations (Scopus)

Abstract

T cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK) lymphocytes constitute an essential component of the innate immune system in tumor surveillance, reproduction, and defense against microbes and viruses. Here, we show that the transcription factor Bcl11b was expressed in all T cell compartments and was indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalScience
Volume329
Issue number5987
DOIs
Publication statusPublished - 2 Jul 2010
Externally publishedYes

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